Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndro...

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Vydané v:	Haematologica (Roma) Ročník 99; číslo 8; s. 1292 - 1303
Hlavní autori:	Heideman, M. R., Lancini, C., Proost, N., Yanover, E., Jacobs, H., Dannenberg, J.-H.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Italy Ferrata Storti Foundation 01.08.2014
Predmet:	Animals Bone Marrow Cells - physiology Cell Lineage - physiology Hematopoiesis - physiology Hematopoietic Stem Cells - metabolism Histone Deacetylase 1 - deficiency Histone Deacetylase 2 - deficiency Homeostasis - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Repressor Proteins - deficiency
ISSN:	0390-6078, 1592-8721, 1592-8721
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