Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndro...

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Bibliographic Details

Published in:	Haematologica (Roma) Vol. 99; no. 8; pp. 1292 - 1303
Main Authors:	Heideman, M. R., Lancini, C., Proost, N., Yanover, E., Jacobs, H., Dannenberg, J.-H.
Format:	Journal Article
Language:	English
Published:	Italy Ferrata Storti Foundation 01.08.2014
Subjects:	Animals Bone Marrow Cells - physiology Cell Lineage - physiology Hematopoiesis - physiology Hematopoietic Stem Cells - metabolism Histone Deacetylase 1 - deficiency Histone Deacetylase 2 - deficiency Homeostasis - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Repressor Proteins - deficiency
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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