Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects

Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods Using the Korean National Health Insurance database, subjects who participated in the health examination program between 20...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:British journal of cancer Ročník 127; číslo 3; s. 549 - 557
Hlavní autoři: Park, Byung Kyu, Seo, Jeong Hun, Chung, Jae Bock, Choi, Jung Kyu
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.08.2022
Nature Publishing Group
Témata:
692/4028/67/1504/1713
692/499
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Cancer Research
Cohort analysis
Cohort Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Drug Resistance
Epidemiology
Humans
Life Style
Molecular Medicine
Obesity
Obesity - complications
Obesity - epidemiology
Oncology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Population studies
Population-based studies
Proportional Hazards Models
Republic of Korea - epidemiology
Risk Factors
Smoking
Republic of Korea
ISSN:0007-0920, 1532-1827, 1532-1827
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model. Results During 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m 2 ) (HR = 1.16; 95% CI, 1.11–1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43–1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38–1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00–2.28). Current smoking combined with BMI ≥ 25 kg/m 2 had an increased risk compared with never smokers with BMI < 23 kg/m 2 (HR = 1.55; 95% CI, 1.46–1.65). Conclusion Smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-022-01807-5