Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tumour vessels. There is interest in expanding the us...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	British journal of cancer Ročník 125; číslo 4; s. 534 - 546
Hlavní autoři:	Sjoberg, Hanna T., Philippou, Yiannis, Magnussen, Anette L., Tullis, Iain D. C., Bridges, Esther, Chatrian, Andrea, Lefebvre, Joel, Tam, Ka Ho, Murphy, Emma A., Rittscher, Jens, Preise, Dina, Agemy, Lilach, Yechezkel, Tamar, Smart, Sean C., Kinchesh, Paul, Gilchrist, Stuart, Allen, Danny P., Scheiblin, David A., Lockett, Stephen J., Wink, David A., Lamb, Alastair D., Mills, Ian G., Harris, Adrian, Muschel, Ruth J., Vojnovic, Boris, Scherz, Avigdor, Hamdy, Freddie C., Bryant, Richard J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 17.08.2021 Nature Publishing Group
Témata:	631/67/1059/485 692/4028/546 Allografts Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Clinical trials Combined Modality Therapy Dose Fractionation, Radiation Drug Resistance Epidemiology Human Umbilical Vein Endothelial Cells Humans Magnetic resonance imaging Male Mice Microenvironments Molecular Medicine Neovascularization, Pathologic - therapy Oncology Permeability Photochemotherapy - methods Photodynamic therapy Prostate cancer Prostatic Neoplasms - blood supply Prostatic Neoplasms - therapy Radiation therapy Survival Analysis Tumor Microenvironment Tumors Xenograft Model Antitumor Assays
ISSN:	0007-0920, 1532-1827, 1532-1827
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tumour vessels. There is interest in expanding the use of VTP to higher-risk disease. Tumour vasculature is characterised by vessel immaturity, increased permeability, aberrant branching and inefficient flow. FRT alters the tumour microenvironment and promotes transient ‘vascular normalisation’. We hypothesised that multimodality therapy combining fractionated radiotherapy (FRT) and VTP could improve PCa tumour control compared against monotherapy with FRT or VTP. Methods We investigated whether sequential delivery of FRT followed by VTP 7 days later improves flank TRAMP-C1 PCa tumour allograft control compared to monotherapy with FRT or VTP. Results FRT induced ‘vascular normalisation’ changes in PCa flank tumour allografts, improving vascular function as demonstrated using dynamic contrast-enhanced magnetic resonance imaging. FRT followed by VTP significantly delayed tumour growth in flank PCa allograft pre-clinical models, compared with monotherapy with FRT or VTP, and improved overall survival. Conclusion Combining FRT and VTP may be a promising multimodal approach in PCa therapy. This provides proof-of-concept for this multimodality treatment to inform early phase clinical trials.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1038/s41416-021-01450-6