Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,000 to 10,000 cells per sample for 48 polyps, 27...

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Veröffentlicht in:	Nature genetics Jg. 54; H. 7; S. 985 - 995
Hauptverfasser:	Becker, Winston R., Nevins, Stephanie A., Chen, Derek C., Chiu, Roxanne, Horning, Aaron M., Guha, Tuhin K., Laquindanum, Rozelle, Mills, Meredith, Chaib, Hassan, Ladabaum, Uri, Longacre, Teri, Shen, Jeanne, Esplin, Edward D., Kundaje, Anshul, Ford, James M., Curtis, Christina, Snyder, Michael P., Greenleaf, William J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2022 Nature Publishing Group
Schlagworte:	631/208/176 631/208/191 631/208/200 631/67 631/67/1504 Accessibility Adenoma - genetics Adenoma - pathology Adenomatous polyposis coli Agriculture Animal Genetics and Genomics Antigen-presenting cells Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell Transformation, Neoplastic - genetics Chromatin Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Composition Datasets DNA methylation DNA Methylation - genetics Epigenetics Fibroblasts Gene expression Gene Function Generalized linear models Genetic transformation Genomics Hepatocyte nuclear factor 4 Homeostasis Human Genetics Humans Immunoregulation Lymphocytes Lymphocytes T Mutation Phenotypes Polyps Runx1 protein Single-Cell Analysis Stems Transcriptomes Tumors
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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