Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver

Adapted fixation methods for electron microscopy allowed us to study liver cell fine structure in 217 biopsies of intact human livers over the course of 10 years. The following novel observations and concepts arose: single fat droplets in parenchymal cells can grow to a volume four times larger than...

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Bibliographic Details
Published in:	Histochemistry and cell biology Vol. 157; no. 1; pp. 27 - 38
Main Authors:	Wisse, Eddie, Braet, Filip, Shami, Gerald J., Zapotoczny, Bartlomiej, Vreuls, Celien, Verhaegh, Pauline, Frederik, Peter, Peters, Peters J., Olde Damink, Steven, Koek, Ger
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022 Springer Nature B.V
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Biopsy Cell Biology Cytoplasm Developmental Biology Electron microscopy Embolism Endothelium Erythrocytes Fatty liver Hepatocytes Hepatocytes - pathology Humans Inflammation Inflammation - metabolism Leukocytes (neutrophilic) Liver Liver - pathology Liver diseases Necrosis Necrosis - metabolism Necrosis - pathology Non-alcoholic Fatty Liver Disease - metabolism Organelles Original Paper Ultrastructure Fat Inflammation Human liver Parenchymal cell Necrosis Steatosis
ISSN:	0948-6143, 1432-119X, 1432-119X
Online Access:	Get full text
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