Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are...

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Veröffentlicht in:	Molecular psychiatry Jg. 29; H. 2; S. 211 - 220
Hauptverfasser:	Belaidi, Abdel Ali, Masaldan, Shashank, Southon, Adam, Kalinowski, Pawel, Acevedo, Karla, Appukuttan, Ambili T., Portbury, Stuart, Lei, Peng, Agarwal, Puja, Leurgans, Sue E., Schneider, Julie, Conrad, Marcus, Bush, Ashley I., Ayton, Scott
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2024 Nature Publishing Group
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/1 13/106 13/109 13/51 14/63 631/378 692/699 82/80 82/83 96/31 Aged Aged, 80 and over AKT protein Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Animals Apolipoprotein E Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Apolipoproteins Apolipoproteins E - genetics Apolipoproteins E - metabolism Autophagy Autopsy Behavioral Sciences Biological Psychology Brain - metabolism Cell death Cerebrospinal fluid Cognitive ability Female Ferritin Ferritins - metabolism Ferroptosis Ferroptosis - drug effects Ferroptosis - physiology Genotype Genotypes Health risk assessment Humans Iron Iron - metabolism Isoforms Lipid peroxidation Lipid Peroxidation - drug effects Male Medicine Medicine & Public Health Neurodegenerative diseases Neuroimaging Neurons - metabolism Neurosciences Pharmacotherapy Polyunsaturated fatty acids Psychiatry Temporal lobe
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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