CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, the...

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Veröffentlicht in:	Trends in cancer Jg. 5; H. 11; S. 724
Hauptverfasser:	Pereira, Brooke A, Vennin, Claire, Papanicolaou, Michael, Chambers, Cecilia R, Herrmann, David, Morton, Jennifer P, Cox, Thomas R, Timpson, Paul
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2019
Schlagworte:	Animals Cancer-Associated Fibroblasts - pathology Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Humans Molecular Targeted Therapy - methods Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Stromal Cells - pathology Tumor Microenvironment CAF heterogeneity CAF subpopulations cancer-associated fibroblasts extracellular matrix (ECM) pancreatic ductal adenocarcinoma (PDAC) desmoplasia stromal targeting fibrosis tumour–stroma crosstalk
ISSN:	2405-8025, 2405-8025
Online-Zugang:	Weitere Angaben
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