Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

The neural mechanisms underlying novelty detection are not well understood, especially in relation to behavior. Here, we present single-unit responses from the primary auditory cortex (A1) from two monkeys trained to detect deviant tones amid repetitive ones. Results show that monkeys can detect dev...

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Vydané v:	Cell reports (Cambridge) Ročník 43; číslo 3; s. 113864
Hlavní autori:	Gong, Yumei, Song, Peirun, Du, Xinyu, Zhai, Yuying, Xu, Haoxuan, Ye, Hangting, Bao, Xuehui, Huang, Qianyue, Tu, Zhiyi, Chen, Pei, Zhao, Xuan, Pérez-González, David, Malmierca, Manuel S., Yu, Xiongjie
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 26.03.2024 Elsevier
Predmet:	Acoustic Stimulation - methods Auditory Cortex - physiology CP: Neuroscience decision making Evoked Potentials, Auditory - physiology macaque monkey Neurons - physiology oddball paradigm P300 predictive coding theory predictive coding theory macaque monkey CP: Neuroscience P300 oddball paradigm decision making
ISSN:	2211-1247, 2211-1247
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Shrnutí:	The neural mechanisms underlying novelty detection are not well understood, especially in relation to behavior. Here, we present single-unit responses from the primary auditory cortex (A1) from two monkeys trained to detect deviant tones amid repetitive ones. Results show that monkeys can detect deviant sounds, and there is a strong correlation between late neuronal responses (250–350 ms after deviant onset) and the monkeys’ perceptual decisions. The magnitude and timing of both neuronal and behavioral responses are increased by larger frequency differences between the deviant and standard tones and by increasing the number of standard tones preceding the deviant. This suggests that A1 neurons encode novelty detection in behaving monkeys, influenced by stimulus relevance and expectations. This study provides evidence supporting aspects of predictive coding in the sensory cortex. [Display omitted] •The primary auditory cortex (A1) neurons encode novelty detection in behaving monkeys•A1 neurons show two distinct responses to deviant stimuli: early (∼100 ms) and late (∼300 ms)•The late response magnitude depends on the number of standard tones preceding deviants•Late neuronal responses in A1 are correlated with the monkeys’ perceptual decisions Gong et al. record single-unit responses from A1 in monkeys trained to perform a novelty detection task. Psychophysical thresholds are close to neuronal thresholds for late responses after the onset of the deviant tone. These late neuronal responses correlate with monkeys’ perceptual decisions and may denote mismatch negativity and/or P300.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2211-1247 2211-1247
DOI:	10.1016/j.celrep.2024.113864