Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials

Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. Motivated by the WIRE trial in renal cell carcinoma (NCT03741426)...

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Vydáno v:	British journal of cancer Ročník 126; číslo 2; s. 204 - 210
Hlavní autoři:	Mossop, Helen, Grayling, Michael J, Gallagher, Ferdia A, Welsh, Sarah J, Stewart, Grant D, Wason, James M S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.02.2022
Témata:	Adaptive Clinical Trials as Topic - methods Cancer therapies Clinical trials Clinical Trials, Phase II as Topic - methods Cohort Studies Computer Simulation - standards Efficiency Humans Hypotheses Kidney cancer Medical Oncology - methods Neoplasms - drug therapy Neoplasms - pathology Non-Randomized Controlled Trials as Topic - methods Oncology Patients Recruitment Renal cell carcinoma Research Design - standards Response rates Sample Size Simulation Surgery Treatment Outcome
ISSN:	0007-0920, 1532-1827, 1532-1827
On-line přístup:	Získat plný text
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