Health-Related Quality of Life After Cytoreductive Surgery/HIPEC for Mucinous Appendiceal Cancer: Results of a Multicenter Randomized Trial Comparing Oxaliplatin and Mitomycin
Background This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin wi...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology Jg. 27; H. 3; S. 772 - 780 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Cham
Springer International Publishing
01.03.2020
Springer Nature B.V |
| Schlagworte: | |
| ISSN: | 1068-9265, 1534-4681, 1534-4681 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Background
This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin.
Methods
In this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m
2
) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally.
Results
Baseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66–0.96;
p
= 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks (
p
= 0.044; score difference 6.35) and 24 weeks after surgery (
p
= 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI (
p
= 0.004; score decline 8.99), PWB (
p
< 0.001; score decline 2.83), and FWB (
p
< 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group.
Conclusions
Compared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC. |
|---|---|
| AbstractList | This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin.BACKGROUNDThis study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin.In this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m2) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally.METHODSIn this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m2) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally.Baseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66-0.96; p = 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks (p = 0.044; score difference 6.35) and 24 weeks after surgery (p = 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI (p = 0.004; score decline 8.99), PWB (p < 0.001; score decline 2.83), and FWB (p < 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group.RESULTSBaseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66-0.96; p = 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks (p = 0.044; score difference 6.35) and 24 weeks after surgery (p = 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI (p = 0.004; score decline 8.99), PWB (p < 0.001; score decline 2.83), and FWB (p < 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group.Compared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC.CONCLUSIONSCompared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC. This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin. In this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m ) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally. Baseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66-0.96; p = 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks (p = 0.044; score difference 6.35) and 24 weeks after surgery (p = 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI (p = 0.004; score decline 8.99), PWB (p < 0.001; score decline 2.83), and FWB (p < 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group. Compared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC. Background This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin. Methods In this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m 2 ) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally. Results Baseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66–0.96; p = 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks ( p = 0.044; score difference 6.35) and 24 weeks after surgery ( p = 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI ( p = 0.004; score decline 8.99), PWB ( p < 0.001; score decline 2.83), and FWB ( p < 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group. Conclusions Compared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC. BackgroundThis study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin.MethodsIn this prospective multicenter study, 121 mucinous appendiceal cancer patients, with evidence of peritoneal dissemination who underwent CRS, were randomized to receive mitomycin (divided 40 mg) or oxaliplatin (200 mg/m2) for HIPEC. The Functional Assessment of Cancer Therapy Neurotoxicity (FACT-G/NTX) questionnaire was utilized to assess HRQOL. The Trial Outcome Index (TOI) is a summary index responsive to changes in physical/functional outcomes. Repeated measures mixed models with an unstructured variance matrix were applied to assess changes in HRQOL longitudinally.ResultsBaseline questionnaire compliance was 95.9%. Baseline physical well-being (PWB) was independently associated with overall survival (hazard ratio 0.79, 95% confidence interval 0.66–0.96; p = 0.017). The TOI was significantly lower in the mitomycin group compared with the oxaliplatin arm at 12 weeks (p = 0.044; score difference 6.35) and 24 weeks after surgery (p = 0.049; score difference 5.61). At 12 weeks after surgery, declines from baseline were significant in the TOI (p = 0.004; score decline 8.99), PWB (p < 0.001; score decline 2.83), and FWB (p < 0.001; score decline 3.42) in the mitomycin group but not the oxaliplatin group.ConclusionsCompared with mitomycin, HIPEC perfusion with oxaliplatin results in significantly better physical and functional outcomes. With similar survival outcomes and complication rates, oxaliplatin should be considered as the chemoperfusion agent of choice in mucinous appendiceal cancer patients undergoing CRS/HIPEC. |
| Author | Mansfield, Paul Shen, Perry McQuellon, Richard Bartlett, David L. Levine, Edward A. Moaven, Omeed Votanopoulos, Konstantinos I. Stewart, John H. Russell, Greg |
| AuthorAffiliation | 3 Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 5 Section of Surgical Oncology, Department of General Surgery, Wake Forest Baptist Health, Winston Salem, NC 2 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 4 Department of Surgery, University of Illinois, Chicago, IL 1 Department of Surgery, Wake Forest University, Winston Salem, NC |
| AuthorAffiliation_xml | – name: 4 Department of Surgery, University of Illinois, Chicago, IL – name: 1 Department of Surgery, Wake Forest University, Winston Salem, NC – name: 2 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA – name: 3 Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX – name: 5 Section of Surgical Oncology, Department of General Surgery, Wake Forest Baptist Health, Winston Salem, NC |
| Author_xml | – sequence: 1 givenname: Omeed surname: Moaven fullname: Moaven, Omeed organization: Department of Surgery, Wake Forest University – sequence: 2 givenname: Konstantinos I. surname: Votanopoulos fullname: Votanopoulos, Konstantinos I. organization: Department of Surgery, Wake Forest University – sequence: 3 givenname: Perry surname: Shen fullname: Shen, Perry organization: Department of Surgery, Wake Forest University – sequence: 4 givenname: Paul surname: Mansfield fullname: Mansfield, Paul organization: Department of Surgical Oncology, MD Anderson Cancer Center – sequence: 5 givenname: David L. surname: Bartlett fullname: Bartlett, David L. organization: Department of Surgery, University of Pittsburgh Medical Center – sequence: 6 givenname: Greg surname: Russell fullname: Russell, Greg organization: Department of Surgery, Wake Forest University – sequence: 7 givenname: Richard surname: McQuellon fullname: McQuellon, Richard organization: Department of Surgery, Wake Forest University – sequence: 8 givenname: John H. surname: Stewart fullname: Stewart, John H. organization: Department of Surgery, University of Illinois – sequence: 9 givenname: Edward A. surname: Levine fullname: Levine, Edward A. email: elevine@wakehealth.edu organization: Department of Surgery, Wake Forest University, Section of Surgical Oncology, Department of General Surgery, Wake Forest Baptist Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31720933$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u1DAUhSNURH_gBVggS2zYhNpxnGRYII2iwlSaqjCUteU4N1NXiR1sp2J4KV6RG6YU6KIrW77fOffYvsfJgXUWkuQlo29ZlovTwGjO85SyRUorWuRp8SQ5YgKP8qJiB7inRZUuskIcJsch3FDKSk7Fs-SQszKjC86Pkp8rUH28TjfQqwgt-Typ3sQdcR1Zmw7IsovgSb2LzkM76WhugXyZ_Bb87nR1_umsJp3z5GLSxropkOU4gm2NRlNSK6vBvyMbCFMfw2ypkOwjlu3sulG2dYP5gW2vvJkVbhiVN3ZLLr9jjBEjGUuQIhcmumGHTZ4nTzvVB3hxt54kXz-cXdWrdH358bxerlOdl3lMGTQNb3JdMKoqoXSn2oY2GljZlLTNFmWlhWpzTVWZcaaqqoNGl1oIzbKG846fJO_3vuPUDNDOib3q5ejNoPxOOmXk_xVrruXW3cqS8rwQHA3e3Bl4922CEOVggoa-VxbwpSS2zTPBK0ERff0AvXGTt3g9pAQt2QJRpF79m-g-yp-_RCDbA9q7EDx09wijch4YuR8YiQMjfw-MLFBUPRBpE_HZ3Xwr0z8u5XtpGOc_A_839iOqX5ke2Nk |
| CitedBy_id | crossref_primary_10_1245_s10434_019_08066_4 crossref_primary_10_32635_2176_9745_RBC_2022v68n1_1696 crossref_primary_10_1245_s10434_021_09973_1 crossref_primary_10_1007_s00464_021_08802_6 crossref_primary_10_1245_s10434_022_12392_5 crossref_primary_10_3390_cancers16213661 crossref_primary_10_1245_s10434_019_08106_z crossref_primary_10_1245_s10434_024_15646_6 crossref_primary_10_1038_s41568_024_00788_2 crossref_primary_10_1245_s10434_023_13941_2 crossref_primary_10_1200_EDBK_321009 crossref_primary_10_1245_s10434_022_12696_6 crossref_primary_10_3390_cancers13133114 crossref_primary_10_3390_cancers14174275 crossref_primary_10_1245_s10434_023_14696_6 crossref_primary_10_1177_17588359221112478 crossref_primary_10_1245_s10434_025_18147_2 crossref_primary_10_1245_s10434_020_08790_2 crossref_primary_10_1245_s10434_024_15997_0 crossref_primary_10_1245_s10434_024_16716_5 crossref_primary_10_3389_fonc_2022_992030 crossref_primary_10_3390_jcm12216799 crossref_primary_10_35509_01239015_933 crossref_primary_10_1245_s10434_022_12933_y |
| Cites_doi | 10.1002/jso.23228 10.1177/1758834010395342 10.1016/j.ejso.2014.08.477 10.1016/j.ejca.2017.07.038 10.1245/s10434-012-2791-7 10.1002/jso.23728 10.1080/00015458.2006.11679897 10.1016/j.ejso.2017.10.216 10.1111/j.1525-1438.2007.00794.x 10.1002/jso.23546 10.1200/JCO.2014.56.7974 10.1046/j.1365-2168.2001.01755.x 10.1016/S1470-2045(09)70200-1 10.1016/j.suronc.2014.10.002 10.1016/0197-2456(89)90005-6 10.1245/s10434-014-4147-y 10.1016/j.jss.2012.01.015 10.1200/JCO.2007.13.3439 10.1586/erp.10.15 10.1245/s10434-016-5547-y 10.1245/s10434-015-4821-8 10.1016/j.ejso.2016.09.015 10.1016/j.jamcollsurg.2017.12.027 10.1245/s10434-013-3049-8 10.1097/PPO.0b013e3181b9c5b9 10.1200/JCO.1996.14.2.671 |
| ContentType | Journal Article |
| Copyright | Society of Surgical Oncology 2019 Annals of Surgical Oncology is a copyright of Springer, (2019). All Rights Reserved. |
| Copyright_xml | – notice: Society of Surgical Oncology 2019 – notice: Annals of Surgical Oncology is a copyright of Springer, (2019). All Rights Reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TO 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1245/s10434-019-08064-6 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Oncogenes and Growth Factors Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1534-4681 |
| EndPage | 780 |
| ExternalDocumentID | PMC7034653 31720933 10_1245_s10434_019_08064_6 |
| Genre | Multicenter Study Comparative Study Randomized Controlled Trial Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA012197 |
| GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .VR 06C 06D 0R~ 0VY 199 1N0 1SB 203 23M 28- 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2WC 2~H 30V 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5VS 67Z 6J9 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABUWZ ABWNU ABXPI ACAOD ACBXY ACDTI ACGFO ACGFS ACHSB ACHVE ACHXU ACIHN ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACREN ACUDM ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYOE ADZKW AEAQA AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFJLC AFKRA AFLOW AFQWF AFWTZ AFYQB AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGVAE AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMTXH AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BAWUL BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI C1A CAG CCPQU COF CS3 CSCUP DDRTE DIK DL5 DNIVK DPUIP E3Z EBD EBLON EBS EIOEI EJD EMOBN EN4 ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GX1 GXS H13 HEOXT HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IH2 IHE IJ- IKXTQ IMOTQ IWAJR IXC IXD IXE IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LLZTM M1P M4Y MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD OWW P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 WOQ YFH YLTOR Z45 Z7U Z7X Z82 Z83 Z87 Z8O Z8V Z91 ZMTXR ZOVNA AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7TO 7XB 8FK H94 K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c474t-1ebb3b4c610a85acfadb0bce17b70d2978c5ad4c0a7231a88febc7c55c12b33f3 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 27 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000496123600005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1068-9265 1534-4681 |
| IngestDate | Tue Nov 04 01:45:42 EST 2025 Thu Sep 04 18:49:01 EDT 2025 Wed Nov 05 14:43:42 EST 2025 Thu Apr 03 07:11:09 EDT 2025 Sat Nov 29 03:28:03 EST 2025 Tue Nov 18 21:40:38 EST 2025 Fri Feb 21 02:33:11 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-1ebb3b4c610a85acfadb0bce17b70d2978c5ad4c0a7231a88febc7c55c12b33f3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/7034653 |
| PMID | 31720933 |
| PQID | 2350719142 |
| PQPubID | 32486 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7034653 proquest_miscellaneous_2314253850 proquest_journals_2350719142 pubmed_primary_31720933 crossref_primary_10_1245_s10434_019_08064_6 crossref_citationtrail_10_1245_s10434_019_08064_6 springer_journals_10_1245_s10434_019_08064_6 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-03-01 |
| PublicationDateYYYYMMDD | 2020-03-01 |
| PublicationDate_xml | – month: 03 year: 2020 text: 2020-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Cham |
| PublicationPlace_xml | – name: Cham – name: United States – name: New York |
| PublicationTitle | Annals of surgical oncology |
| PublicationTitleAbbrev | Ann Surg Oncol |
| PublicationTitleAlternate | Ann Surg Oncol |
| PublicationYear | 2020 |
| Publisher | Springer International Publishing Springer Nature B.V |
| Publisher_xml | – name: Springer International Publishing – name: Springer Nature B.V |
| References | Shan, Saxena, Shan, Morris (CR19) 2014; 23 Trask, Hsu, McQuellon (CR16) 2009; 15 Hompes, D’Hoore, Wolthuis (CR23) 2014; 109 Langenhoff, Krabbe, Wobbes, Ruers (CR5) 2001; 88 Osoba (CR9) 2011; 3 Au, Ringash, Brundage (CR6) 2010; 10 Wagner, Austin, Maduekwe (CR3) 2013; 20 Dodson, McQuellon, Mogal (CR4) 2016; 23 Leung, Huo, Liauw, Morris (CR20) 2017; 43 Seretis, Youssef (CR18) 2014; 40 Gotay, Kawamoto, Bottomley, Efficace (CR11) 2008; 26 Ihemelandu, McQuellon, Shen, Stewart, Votanopoulos, Levine (CR17) 2013; 20 van Eden, Kok, Woensdregt, Huitema, Boot, Aalbers (CR24) 2018; 44 Huang, Brady, Cella, Fleming (CR14) 2007; 17 Votanopoulos, Ihemelandu, Shen, Stewart, Russell, Levine (CR25) 2013; 179 Rouers, Laurent, Detroz, Meurisse (CR26) 2006; 106 Votanopoulos, Russell, Randle, Shen, Stewart, Levine (CR1) 2015; 22 CR8 Calhoun, Welshman, Chang (CR13) 2003; 13 Prada-Villaverde, Esquivel, Lowy (CR21) 2014; 110 Jaeschke, Singer, Guyatt (CR15) 1989; 10 Bonnetain, Fiteni, Efficace, Anota (CR27) 2016; 34 Levine, Votanopoulos, Shen (CR12) 2018; 226 Glockzin, von Breitenbuch, Schlitt, Piso (CR22) 2013; 107 Bascoul-Mollevi, Gourgou, Galais (CR10) 2017; 84 Quinten, Coens, Mauer (CR7) 2009; 10 Mogal, Levine, Russell, Shen, Stewart, Votanopoulos (CR2) 2016; 23 CU Ihemelandu (8064_CR17) 2013; 20 CC Gotay (8064_CR11) 2008; 26 BS Langenhoff (8064_CR5) 2001; 88 A Rouers (8064_CR26) 2006; 106 EA Calhoun (8064_CR13) 2003; 13 C Quinten (8064_CR7) 2009; 10 LL Shan (8064_CR19) 2014; 23 EA Levine (8064_CR12) 2018; 226 HQ Huang (8064_CR14) 2007; 17 HD Mogal (8064_CR2) 2016; 23 C Seretis (8064_CR18) 2014; 40 G Glockzin (8064_CR22) 2013; 107 PL Wagner (8064_CR3) 2013; 20 PC Trask (8064_CR16) 2009; 15 K Votanopoulos (8064_CR25) 2013; 179 D Hompes (8064_CR23) 2014; 109 WJ van Eden (8064_CR24) 2018; 44 HJ Au (8064_CR6) 2010; 10 RM Dodson (8064_CR4) 2016; 23 A Prada-Villaverde (8064_CR21) 2014; 110 F Bonnetain (8064_CR27) 2016; 34 D Osoba (8064_CR9) 2011; 3 C Bascoul-Mollevi (8064_CR10) 2017; 84 KI Votanopoulos (8064_CR1) 2015; 22 V Leung (8064_CR20) 2017; 43 Roman Jaeschke (8064_CR15) 1989; 10 8064_CR8 31848812 - Ann Surg Oncol. 2020 Mar;27(3):630-631 |
| References_xml | – volume: 107 start-page: 574 issue: 6 year: 2013 end-page: 578 ident: CR22 article-title: Treatment-related morbidity and toxicity of CRS and oxaliplatin-based HIPEC compared to a mitomycin and doxorubicin-based HIPEC protocol in patients with peritoneal carcinomatosis: a matched-pair analysis publication-title: J Surg Oncol doi: 10.1002/jso.23228 – volume: 3 start-page: 57 issue: 2 year: 2011 end-page: 71 ident: CR9 article-title: Health-related quality of life and cancer clinical trials publication-title: Ther Adv Med Oncol doi: 10.1177/1758834010395342 – volume: 40 start-page: 1605 issue: 12 year: 2014 end-page: 1613 ident: CR18 article-title: Quality of life after cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies: a systematic review publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2014.08.477 – volume: 84 start-page: 239 year: 2017 end-page: 249 ident: CR10 article-title: Health-related quality of life results from the PRODIGE 5/ACCORD 17 randomised trial of FOLFOX versus fluorouracil-cisplatin regimen in oesophageal cancer publication-title: Eur J Cancer doi: 10.1016/j.ejca.2017.07.038 – volume: 20 start-page: 1056 issue: 4 year: 2013 end-page: 1062 ident: CR3 article-title: Extensive cytoreductive surgery for appendiceal carcinomatosis: morbidity, mortality, and survival publication-title: Ann Surg Oncol. doi: 10.1245/s10434-012-2791-7 – volume: 110 start-page: 779 issue: 7 year: 2014 end-page: 785 ident: CR21 article-title: The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery publication-title: J Surg Oncol doi: 10.1002/jso.23728 – volume: 106 start-page: 302 issue: 3 year: 2006 end-page: 306 ident: CR26 article-title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: higher complication rate for oxaliplatin compared to Mitomycin C publication-title: Acta Chir Belg doi: 10.1080/00015458.2006.11679897 – volume: 44 start-page: 220 issue: 2 year: 2018 end-page: 227 ident: CR24 article-title: Safety of intraperitoneal Mitomycin C versus intraperitoneal oxaliplatin in patients with peritoneal carcinomatosis of colorectal cancer undergoing cytoreductive surgery and HIPEC publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2017.10.216 – volume: 17 start-page: 387 issue: 2 year: 2007 end-page: 393 ident: CR14 article-title: Validation and reduction of FACT/GOG-Ntx subscale for platinum/paclitaxel-induced neurologic symptoms: a gynecologic oncology group study publication-title: Int J Gynecol Cancer doi: 10.1111/j.1525-1438.2007.00794.x – ident: CR8 – volume: 109 start-page: 527 issue: 6 year: 2014 end-page: 532 ident: CR23 article-title: The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: a comparative study publication-title: J Surg Oncol doi: 10.1002/jso.23546 – volume: 34 start-page: 1953 issue: 16 year: 2016 end-page: 1956 ident: CR27 article-title: Statistical challenges in the analysis of health-related quality of life in cancer clinical trials publication-title: J Clin Oncol doi: 10.1200/JCO.2014.56.7974 – volume: 88 start-page: 643 issue: 5 year: 2001 end-page: 652 ident: CR5 article-title: Quality of life as an outcome measure in surgical oncology publication-title: Br J Surg doi: 10.1046/j.1365-2168.2001.01755.x – volume: 10 start-page: 865 issue: 9 year: 2009 end-page: 871 ident: CR7 article-title: Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials publication-title: Lancet Oncol doi: 10.1016/S1470-2045(09)70200-1 – volume: 23 start-page: 199 issue: 4 year: 2014 end-page: 210 ident: CR19 article-title: Quality of life after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy for peritoneal carcinomatosis: a systematic review and meta-analysis publication-title: Surg Oncol doi: 10.1016/j.suronc.2014.10.002 – volume: 10 start-page: 407 issue: 4 year: 1989 end-page: 415 ident: CR15 article-title: Measurement of health status publication-title: Controlled Clinical Trials doi: 10.1016/0197-2456(89)90005-6 – volume: 22 start-page: 1274 issue: 4 year: 2015 end-page: 1279 ident: CR1 article-title: Peritoneal surface disease (PSD) from appendiceal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): overview of 481 cases publication-title: Ann Surg Oncol. doi: 10.1245/s10434-014-4147-y – volume: 179 start-page: e133 issue: 1 year: 2013 end-page: e139 ident: CR25 article-title: A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin C publication-title: J Surg Res doi: 10.1016/j.jss.2012.01.015 – volume: 26 start-page: 1355 issue: 8 year: 2008 end-page: 1363 ident: CR11 article-title: The prognostic significance of patient-reported outcomes in cancer clinical trials publication-title: J Clin Oncol doi: 10.1200/JCO.2007.13.3439 – volume: 13 start-page: 741 issue: 6 year: 2003 end-page: 748 ident: CR13 article-title: Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy publication-title: Int J Gynecol Cancer – volume: 10 start-page: 119 issue: 2 year: 2010 end-page: 128 ident: CR6 article-title: Added value of health-related quality of life measurement in cancer clinical trials: the experience of the NCIC CTG publication-title: Exp Rev Pharmacoecon Outcomes Res doi: 10.1586/erp.10.15 – volume: 23 start-page: 772 issue: Suppl 5 year: 2016 end-page: 783 ident: CR4 article-title: Quality-of-life evaluation after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy publication-title: Ann Surg Oncol doi: 10.1245/s10434-016-5547-y – volume: 23 start-page: 534 issue: 2 year: 2016 end-page: 538 ident: CR2 article-title: Conditional Survival After Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy for Low- and High-Grade Appendiceal Primaries publication-title: Ann Surg Oncol. doi: 10.1245/s10434-015-4821-8 – volume: 43 start-page: 144 issue: 1 year: 2017 end-page: 149 ident: CR20 article-title: Oxaliplatin versus Mitomycin C for HIPEC in colorectal cancer peritoneal carcinomatosis publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2016.09.015 – volume: 226 start-page: 434 issue: 4 year: 2018 end-page: 443 ident: CR12 article-title: A multicenter randomized trial to evaluate hematologic toxicities after hyperthermic intraperitoneal chemotherapy with oxaliplatin or mitomycin in patients with appendiceal tumors publication-title: J Am Coll Surg doi: 10.1016/j.jamcollsurg.2017.12.027 – volume: 20 start-page: 3519 issue: 11 year: 2013 end-page: 3526 ident: CR17 article-title: Predicting postoperative morbidity following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CS + HIPEC) with preoperative FACT-C (Functional Assessment of Cancer Therapy) and patient-rated performance status publication-title: Ann Surg Oncol doi: 10.1245/s10434-013-3049-8 – volume: 15 start-page: 435 issue: 5 year: 2009 end-page: 440 ident: CR16 article-title: Other paradigms: health-related quality of life as a measure in cancer treatment: its importance and relevance publication-title: Cancer J doi: 10.1097/PPO.0b013e3181b9c5b9 – volume: 22 start-page: 1274 issue: 4 year: 2015 ident: 8064_CR1 publication-title: Ann Surg Oncol. doi: 10.1245/s10434-014-4147-y – volume: 44 start-page: 220 issue: 2 year: 2018 ident: 8064_CR24 publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2017.10.216 – volume: 15 start-page: 435 issue: 5 year: 2009 ident: 8064_CR16 publication-title: Cancer J doi: 10.1097/PPO.0b013e3181b9c5b9 – volume: 43 start-page: 144 issue: 1 year: 2017 ident: 8064_CR20 publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2016.09.015 – volume: 88 start-page: 643 issue: 5 year: 2001 ident: 8064_CR5 publication-title: Br J Surg doi: 10.1046/j.1365-2168.2001.01755.x – volume: 20 start-page: 3519 issue: 11 year: 2013 ident: 8064_CR17 publication-title: Ann Surg Oncol doi: 10.1245/s10434-013-3049-8 – volume: 84 start-page: 239 year: 2017 ident: 8064_CR10 publication-title: Eur J Cancer doi: 10.1016/j.ejca.2017.07.038 – volume: 109 start-page: 527 issue: 6 year: 2014 ident: 8064_CR23 publication-title: J Surg Oncol doi: 10.1002/jso.23546 – volume: 179 start-page: e133 issue: 1 year: 2013 ident: 8064_CR25 publication-title: J Surg Res doi: 10.1016/j.jss.2012.01.015 – volume: 17 start-page: 387 issue: 2 year: 2007 ident: 8064_CR14 publication-title: Int J Gynecol Cancer doi: 10.1111/j.1525-1438.2007.00794.x – volume: 10 start-page: 865 issue: 9 year: 2009 ident: 8064_CR7 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(09)70200-1 – volume: 110 start-page: 779 issue: 7 year: 2014 ident: 8064_CR21 publication-title: J Surg Oncol doi: 10.1002/jso.23728 – volume: 3 start-page: 57 issue: 2 year: 2011 ident: 8064_CR9 publication-title: Ther Adv Med Oncol doi: 10.1177/1758834010395342 – volume: 20 start-page: 1056 issue: 4 year: 2013 ident: 8064_CR3 publication-title: Ann Surg Oncol. doi: 10.1245/s10434-012-2791-7 – volume: 107 start-page: 574 issue: 6 year: 2013 ident: 8064_CR22 publication-title: J Surg Oncol doi: 10.1002/jso.23228 – ident: 8064_CR8 doi: 10.1200/JCO.1996.14.2.671 – volume: 13 start-page: 741 issue: 6 year: 2003 ident: 8064_CR13 publication-title: Int J Gynecol Cancer – volume: 106 start-page: 302 issue: 3 year: 2006 ident: 8064_CR26 publication-title: Acta Chir Belg doi: 10.1080/00015458.2006.11679897 – volume: 10 start-page: 119 issue: 2 year: 2010 ident: 8064_CR6 publication-title: Exp Rev Pharmacoecon Outcomes Res doi: 10.1586/erp.10.15 – volume: 23 start-page: 534 issue: 2 year: 2016 ident: 8064_CR2 publication-title: Ann Surg Oncol. doi: 10.1245/s10434-015-4821-8 – volume: 26 start-page: 1355 issue: 8 year: 2008 ident: 8064_CR11 publication-title: J Clin Oncol doi: 10.1200/JCO.2007.13.3439 – volume: 10 start-page: 407 issue: 4 year: 1989 ident: 8064_CR15 publication-title: Controlled Clinical Trials doi: 10.1016/0197-2456(89)90005-6 – volume: 23 start-page: 772 issue: Suppl 5 year: 2016 ident: 8064_CR4 publication-title: Ann Surg Oncol doi: 10.1245/s10434-016-5547-y – volume: 226 start-page: 434 issue: 4 year: 2018 ident: 8064_CR12 publication-title: J Am Coll Surg doi: 10.1016/j.jamcollsurg.2017.12.027 – volume: 40 start-page: 1605 issue: 12 year: 2014 ident: 8064_CR18 publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2014.08.477 – volume: 34 start-page: 1953 issue: 16 year: 2016 ident: 8064_CR27 publication-title: J Clin Oncol doi: 10.1200/JCO.2014.56.7974 – volume: 23 start-page: 199 issue: 4 year: 2014 ident: 8064_CR19 publication-title: Surg Oncol doi: 10.1016/j.suronc.2014.10.002 – reference: 31848812 - Ann Surg Oncol. 2020 Mar;27(3):630-631 |
| SSID | ssj0017305 |
| Score | 2.4395456 |
| Snippet | Background
This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who... This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent... BackgroundThis study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 772 |
| SubjectTerms | Adenocarcinoma, Mucinous - secondary Adenocarcinoma, Mucinous - therapy Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Appendiceal Neoplasms - pathology Appendiceal Neoplasms - therapy Appendix Cancer Chemotherapy Combined Modality Therapy Cytoreduction Surgical Procedures Female Gastrointestinal cancer Health Status Humans Hyperthermia, Induced Male Medicine Medicine & Public Health Middle Aged Mitomycin Mitomycin - adverse effects Mitomycin - therapeutic use Neurotoxicity Oncology Oxaliplatin Oxaliplatin - adverse effects Oxaliplatin - therapeutic use Patient Reported Outcome Measures Perfusion Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Peritoneal Surface Malignancy Peritoneum Prospective Studies Quality of Life Questionnaires Surgery Surgical Oncology Survival Survival Rate Well being Young Adult |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLZgILQX7pfAQEbiDawljh0nvKCp2jQkOqYxpL5FvgUqbUnXtIjyp_iLnOOkmcrEXni2a8f1d24-N0LeVFqY3GWcgTDzDCjRMx27jIGx5YRTIEMKE5pNqKOjfDIpjvsHt7YPq1zzxMCoXWPxjXyXp6i5FIngH2YXDLtGoXe1b6Fxk9zCttlYO19NBoMrAfTK4O3MgKh5JvukGS4kps6JFOMvCgY6UyZYtimYrmibV4Mm__KcBoF0cO9_j3Kf3O1VUbrXYecBueHrh-TOuHe2PyK_uxQlFuLlvKNduY0VbSr6aVp5uoftxeloBVY71n9Fvkm_dFnWu4cfj_dHFBRiOl7Cas2ypaDv-hrWhkXpCLE2f09PfLs8W7S4pKYhFxjPDaue6No159NfsO0pkggddf0S62_080_4jBmG8NUUZtEx8KTzFWzymHw92D8dHbK-vwOzQokFS7wxqREWNDidS20r7UxsrE-UUbHjYN9aqZ2wsVagheo8r7yxykppE27StEqfkK26qf0zQmMtjU2FlB7AB0xcFzYTVqWV9YXWPI9Isr7c0vbFz7EHx1mJRhAAouwAUQIgygCIMovI2-E3s670x7Wzd9aXXfZsoC0vbzoir4dhIGD0yujaw78Pc2AYxI6MI_K0g9iwHSh3HJ-cIqI2wDdMwOLgmyP19HsoEg6cHEvnReTdGqaXn_XvUzy__hQvyDbH94YQg7dDthbzpX9Jbtsfi2k7fxWI7w8irjhf priority: 102 providerName: ProQuest |
| Title | Health-Related Quality of Life After Cytoreductive Surgery/HIPEC for Mucinous Appendiceal Cancer: Results of a Multicenter Randomized Trial Comparing Oxaliplatin and Mitomycin |
| URI | https://link.springer.com/article/10.1245/s10434-019-08064-6 https://www.ncbi.nlm.nih.gov/pubmed/31720933 https://www.proquest.com/docview/2350719142 https://www.proquest.com/docview/2314253850 https://pubmed.ncbi.nlm.nih.gov/PMC7034653 |
| Volume | 27 |
| WOSCitedRecordID | wos000496123600005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1534-4681 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017305 issn: 1068-9265 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3bbtMw9IhtCPHCfRAYlZF4A4tc7DjhbUSdhkRL1Q3Ut8h2HKi0pVPTTis_xS9y7FxQGSDBS198ehznXJ1zA3hZSqaSIg4pGjNDURINlX4RU7xsFawQaENS5YZNiPE4mc3SSVsUVnfZ7l1I0mlq1wGBcVvsxiKbMZFS9HJiRuMd2ENzl1hxnJ587mMHyLPcxThjFOUw5m2pzO9xbJujaz7m9VTJX-Klzgwd3f2_A9yDO63bSQ4bPrkPN0z1AG6N2sD6Q_jelCNRlxtnCtK01tiQRUk-zEtDDu0ocZJt8IZue71aHUlOmorqN8fvJ8OMoPNLRmvEtljXBH1bUyFuREoyy1fLt2Rq6vXZqrYoJXF1v_a0iHUqq2JxPv-G255acSBZMxux-kI-XuFjXNh0vYogFBmh_jnf4CaP4NPR8DQ7pu0sB6qZYCsaGKUixTR6azLhUpeyUL7SJhBK-EWId1nNZcG0LwV6nDJJSqO00JzrIFRRVEb7sFstKvMEiC-50hHj3CCjocKWqY6ZFlGpTSplmHgQdCTNddvo3M7bOMvthQcpkTeUyJESuaNEHnvwqv_PRdPm46_QBx2n5K3I13kYWdc6DVjowYt-GYXVRmBkZfDtIwwuo4nhvgePG8bqt0NHLrSflzwQWyzXA9hG4Nsr1fyrawiOWtu2yfPgdcd4Px_rz6d4-m_gz-B2aL81uPy7A9hdLdfmOdzUl6t5vRzAjpgJ95sMYO_dcDyZDpxY_gBP6zIA |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQMAL90tggJHgCawljp0LEkJT2dRqbZlGJ_Ut2I4DlbakNC1QfhT8Rc7JpVOZ2NseePbJceJ852L7XAh5kSmhozTgDIyZZSCJlik3DRhstlKRhmBDYl01mwiHw2g8jg82yK82FwbDKludWCnqtDB4Rr7NffRcYk_wd9OvDLtG4e1q20KjhsW-XX6HLVv5tvce_u9Lzvd2R50ua7oKMCNCMWee1drXwoDfoCKpTKZS7WpjvVCHbsphV2WkSoVxVQi-j4qizGoTGimNx7XvZz7wvUQuC6QE-QnHqw2eB9Iiq9vVAJQID2STpMOFxFQ94WO8R8zARwsEC9YN4Rnv9myQ5l83tZUB3Lv5vy3dLXKjcbXpTi0bt8mGze-Qq4MmmOAu-V2nYLEqHtCmtC4nsqRFRvuTzNIdbJ9OO8t5McP6tmgX6Mc6i3y72zvY7VBw-OlgAdyKRUnBn7c58AamtIOyNHtDD225OJ6XyFLRKtcZ1xm4Hqo8LU4mP2HaEaoA2qn7Qeaf6Ycf8BpTDFHMKVDRAejckyVMco8cXchy3SebeZHbh4S6SmrjCyktCBcYKRWbQJjQz4yNleKRQ7wWTIlpirtjj5HjBDd5AMCkBmACAEwqACaBQ16tnpnWpU3Opd5qwZU0aq5MTpHlkOerYVBQeOukcgurDzQwDGZVug55UEN6NR04rxyP1BwSroF9RYDFz9dH8smXqgg6WCosDeiQ161YnL7Wv7_i0flf8Yxc644G_aTfG-4_Jtc5nq1U8YZbZHM-W9gn5Ir5Np-Us6eV4FPy6aLF5Q9zl5iL |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQBMv3C-BAUaCJ7CaOHacICE0datWbS3VGFLfguM4UGlLStMC5U_xzq_jnFw6lYm97YFnO8eJ852bfS6EvMi0SMI04AyUmWXAiZZpNw0YOFupSBXokCipmk2o4TAcj6PRBvnd5sJgWGUrEytBnRYGz8g73EfLJfIE72RNWMRot_du-pVhBym8aW3badQQObDL7-C-lW_7u_CvX3Le2zvu7rOmwwAzQok582yS-IkwYEPoUGqT6TRxE2M9lSg35eBhGalTYVytwA7SYZjZxCgjpfF44vuZD3SvkKvK9xW2jVDjlbPnAefI6qY1AIHCA9kk7HAhMW1P-Bj7ETGw1wLBgnWleM7SPR-w-detbaUMezf_5228RW40JjjdqXnmNtmw-R2yNWiCDO6SX3VqFqviBG1K6zIjS1pk9HCSWbqDbdVpdzkvZlj3FvUF_VBnl3f2-6O9LgVHgA4WQK1YlBTsfJsDbSBKu8hjszf0yJaLk3mJJDWtcqBxz4Hqkc7T4nTyE5Y9RtFAu3WfyPwzff8DXmOKoYs5hVl0ALL4dAmL3CMfL2W77pPNvMjtQ0JdLRPjCyktMB0oLx2ZQBjlZ8ZGWvPQIV4LrNg0Rd-x98hJjM4fgDGuwRgDGOMKjHHgkFerZ6Z1yZMLZ2-3QIsb8VfGZyhzyPPVMAguvI3SuYXdhzkwDOpWug55UMN7tRwYtRyP2hyi1oC_moBF0ddH8smXqjg6aDAsGeiQ1y2LnL3Wv7_i0cVf8YxsAZfEh_3hwWNyneORSxWGuE0257OFfUKumW_zSTl7WskASj5dNrf8AfqeoT8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Health-Related+Quality+of+Life+After+Cytoreductive+Surgery%2FHIPEC+for+Mucinous+Appendiceal+Cancer%3A+Results+of+a+Multicenter+Randomized+Trial+Comparing+Oxaliplatin+and+Mitomycin&rft.jtitle=Annals+of+surgical+oncology&rft.au=Moaven%2C+Omeed&rft.au=Votanopoulos%2C+Konstantinos+I.&rft.au=Shen%2C+Perry&rft.au=Mansfield%2C+Paul&rft.date=2020-03-01&rft.pub=Springer+International+Publishing&rft.issn=1068-9265&rft.eissn=1534-4681&rft.volume=27&rft.issue=3&rft.spage=772&rft.epage=780&rft_id=info:doi/10.1245%2Fs10434-019-08064-6&rft.externalDocID=10_1245_s10434_019_08064_6 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1068-9265&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1068-9265&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1068-9265&client=summon |