Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors

It is essential to identify the neuronal mechanisms of Alzheimer's Disease (AD)-associated neuropsychiatric symptoms, e.g., apathy, before improving the life quality of AD patients. Here, we focused on the nucleus accumbens (NAc), a critical brain region processing motivation, also known to dis...

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Vydané v:	Molecular psychiatry Ročník 27; číslo 4; s. 2146 - 2157
Hlavní autori:	Guo, Changyong, Wen, Di, Zhang, Yihong, Mustaklem, Richie, Mustaklem, Basil, Zhou, Miou, Ma, Tao, Ma, Yao-Ying
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Nature Publishing Group 01.04.2022
Predmet:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Calcium - metabolism Calcium permeability Emotional behavior Humans Mental disorders Motivation Neurodegeneration Neurodegenerative diseases Nucleus accumbens Nucleus Accumbens - metabolism Oligomers Quality of life Receptors, AMPA - metabolism Receptors, Calcium-Sensing Synapses - metabolism Synaptic transmission α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors β-Amyloid
ISSN:	1359-4184, 1476-5578, 1476-5578
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