Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis

Activated protein C exerts its anticoagulant activity by protein S-dependent inactivation of factors Va and VIIIa by limited proteolysis. We identified a venous thrombosis patient who has plasma protein C antigen level of 63% and activity levels of 44% and 23%, as monitored by chromogenic and clotti...

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Veröffentlicht in:	Haematologica (Roma) Jg. 105; H. 6; S. 1712 - 1722
Hauptverfasser:	Lu, Yeling, Mehta-D’souza, Padmaja, Biswas, Indranil, Villoutreix, Bruno O., Wang, Xuefeng, Ding, Qiulan, Rezaie, Alireza R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Italy Ferrata Storti Foundation 01.06.2020
Schlagworte:	Epidermal Growth Factor Glycosylation Humans Mutation Protein C - genetics Protein C - metabolism Thrombin - metabolism Thrombosis - genetics
ISSN:	0390-6078, 1592-8721, 1592-8721
Online-Zugang:	Volltext
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