Motor Unit Discharge Patterns in Response to Focal Tendon Vibration of the Lower Limb in Cats and Humans

High-frequency vibration of the tendon provides potent activation of Ia afferents time-locked to the stimulation frequency and provides excitatory ionotropic activation of homonymous motor pools. In cats, the evoked motor unit discharge is constrained to discharge at integer multiples of the vibrati...

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Vydané v:Frontiers in integrative neuroscience Ročník 16; s. 836757
Hlavní autori: Thompson, Christopher K., Johnson, Michael D., Negro, Francesco, Farina, Dario, Heckman, C. J.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Research Foundation 26.04.2022
Frontiers Media S.A
Predmet:
Action potential
Animals
cat
Catheters
Electrodes
electromyogram (EMG)
Electromyography
Experiments
human
motor unit
Neuroscience
Ostomy
reflex
Spinal cord
Surgery
tendon vibration
motor unit
electromyogram (EMG)
reflex
tendon vibration
human
cat
ISSN:1662-5145, 1662-5145
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Shrnutí:High-frequency vibration of the tendon provides potent activation of Ia afferents time-locked to the stimulation frequency and provides excitatory ionotropic activation of homonymous motor pools. In cats, the evoked motor unit discharge is constrained to discharge at integer multiples of the vibration frequency, resulting in a probability of discharge that is highly punctuated. Here we quantify the robustness of this punctuated response in the cat and evaluate whether it is present in the human. Soleus electromyography (EMG) was collected from eight cats using 64 channel electrodes during three modes of motoneuron activation. First, tendon vibration parameters were modified. Second, secondary reflex inputs are applied concurrently with tendon vibration. Third, the state of the spinal cord was altered through pharmacological or surgical manipulations. Analogous surface high-density EMG was collected from the lower leg of six humans during both vibration evoked and matched volitional contractions. Array EMG signals from both the cat and human were decomposed into corresponding motor unit action potential spike trains, and the punctuation in discharge was quantified. In the cat, regardless of vibration parameters, secondary synaptic drive, and state of spinal circuitry, focal tendon vibration evoked punctuated motor unit discharge. However, in the human lower limb, the vibration-evoked contractions do not produce punctuated motor unit discharge.
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Edited by: Richard Nichols, Georgia Institute of Technology, United States
Reviewed by: Ken Muramatsu, Kyorin University, Japan; Leonardo Gizzi, Fraunhofer Institute for Manufacturing Engineering and Automation, Germany
ISSN:1662-5145
1662-5145
DOI:10.3389/fnint.2022.836757