A computational implementation and comparison of several intensity modulated proton therapy treatment planning algorithms

The authors present a comparative study of intensity modulated proton therapy (IMPT) treatment planning employing algorithms of three-dimensional (3D) modulation, and 2.5-dimensional (2.5D) modulation, and intensity modulated distal edge tracking (DET) [A. Lomax, Phys. Med. Biol. 44, 185–205 (1999)]...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Medical physics (Lancaster) Ročník 35; číslo 3; s. 1103 - 1112
Hlavní autoři: Li, Haisen S., Romeijn, H. Edwin, Fox, Christopher, Palta, Jatinder R., Dempsey, James F.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Association of Physicists in Medicine 01.03.2008
Témata:
2.5D modulation
3D modulation
ALGORITHMS
Anatomy
Brain
Cancer
DET
DOSIMETRY
Dosimetry/exposure assessment
fluence map optimization
Head - radiation effects
Humans
IMPT
Intensity modulated radiation therapy
Medical treatment planning
MODULATION
Neck - radiation effects
NEOPLASMS
optimisation
OPTIMIZATION
ORGANS
pencil beam
Photons
PLANNING
PROTON BEAMS
proton therapy
Protons
Protons - therapeutic use
RADIATION DOSES
radiation therapy
RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated - methods
Tissues
Treatment planning
treatment planning
proton therapy
3D modulation
DET
2.5D modulation
IMPT
pencil beam
fluence map optimization
ISSN:0094-2405, 2473-4209
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The authors present a comparative study of intensity modulated proton therapy (IMPT) treatment planning employing algorithms of three-dimensional (3D) modulation, and 2.5-dimensional (2.5D) modulation, and intensity modulated distal edge tracking (DET) [A. Lomax, Phys. Med. Biol. 44, 185–205 (1999)] applied to the treatment of head-and-neck cancer radiotherapy. These three approaches were also compared with 6 MV photon intensity modulated radiation therapy (IMRT). All algorithms were implemented in the University of Florida Optimized Radiation Therapy system using a finite sized pencil beam dose model and a convex fluence map optimization model. The 3D IMPT and the DET algorithms showed considerable advantages over the photon IMRT in terms of dose conformity and sparing of organs at risk when the beam number was not constrained. The 2.5D algorithm did not show an advantage over the photon IMRT except in the dose reduction to the distant healthy tissues, which is inherent in proton beam delivery. The influences of proton beam number and pencil beam size on the IMPT plan quality were also studied. Out of 24 cases studied, three cases could be adequately planned with one beam and 12 cases could be adequately planned with two beams, but the dose uniformity was often marginally acceptable. Adding one or two more beams in each case dramatically improved the dose uniformity. The finite pencil beam size had more influence on the plan quality of the 2.5D and DET algorithms than that of the 3D IMPT. To obtain a satisfactory plan quality, a 0.5 cm pencil beam size was required for the 3D IMPT and a 0.3 cm size was required for the 2.5D and the DET algorithms. Delivery of the IMPT plans produced in this study would require a proton beam spot scanning technique that has yet to be developed clinically.
Bibliografie:dempsey@ufl.edu
Electronic mail
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0094-2405
2473-4209
DOI:10.1118/1.2836954