Immunotherapy: State-of-the-art review of therapies and theratypes

Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation...

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Vydáno v:Journal of allergy and clinical immunology Ročník 150; číslo 6; s. 1279 - 1288
Hlavní autoři: Agache, Ioana, Zemelka-Wiącek, Magdalena, Shamji, Mohamed H., Jutel, Marek
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.12.2022
Témata:
Allergen
biologicals
biomarkers
endotypes
immunotherapy
theratype
ILC
HETE
HDM
immunotherapy
TFH
miRNA
SCIT
T2
CRISPR
RWE
TFR
SLIT
AD
biomarkers
Treg
AIT
endotypes
biologicals
AR
CAR
EAR
OIT
LAR
theratype
cTFH
Allergen
DC
ISSN:0091-6749, 1097-6825, 1097-6825
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Popis
Shrnutí:Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation network. In this review, a summary of the most significant advances in immunotherapy is presented, addressing not only novel approaches to stratifying patients but also major controlled clinical trials and real-world evidence that strengthen the role of immunotherapy in the treatment of allergies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2022.10.007