Immunotherapy: State-of-the-art review of therapies and theratypes

Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology Jg. 150; H. 6; S. 1279 - 1288
Hauptverfasser: Agache, Ioana, Zemelka-Wiącek, Magdalena, Shamji, Mohamed H., Jutel, Marek
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.12.2022
Schlagworte:
Allergen
biologicals
biomarkers
endotypes
immunotherapy
theratype
ILC
HETE
HDM
immunotherapy
TFH
miRNA
SCIT
T2
CRISPR
RWE
TFR
SLIT
AD
biomarkers
Treg
AIT
endotypes
biologicals
AR
CAR
EAR
OIT
LAR
theratype
cTFH
Allergen
DC
ISSN:0091-6749, 1097-6825, 1097-6825
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation network. In this review, a summary of the most significant advances in immunotherapy is presented, addressing not only novel approaches to stratifying patients but also major controlled clinical trials and real-world evidence that strengthen the role of immunotherapy in the treatment of allergies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2022.10.007