Immunotherapy: State-of-the-art review of therapies and theratypes

Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 150; no. 6; pp. 1279 - 1288
Main Authors: Agache, Ioana, Zemelka-Wiącek, Magdalena, Shamji, Mohamed H., Jutel, Marek
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.12.2022
Subjects:
Allergen
biologicals
biomarkers
endotypes
immunotherapy
theratype
ILC
HETE
HDM
immunotherapy
TFH
miRNA
SCIT
T2
CRISPR
RWE
TFR
SLIT
AD
biomarkers
Treg
AIT
endotypes
biologicals
AR
CAR
EAR
OIT
LAR
theratype
cTFH
Allergen
DC
ISSN:0091-6749, 1097-6825, 1097-6825
Online Access:Get full text
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Summary:Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation network. In this review, a summary of the most significant advances in immunotherapy is presented, addressing not only novel approaches to stratifying patients but also major controlled clinical trials and real-world evidence that strengthen the role of immunotherapy in the treatment of allergies.
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ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2022.10.007