Applications of the oral microbiome in personalized dentistry

•Dysbiotic changes of the oral microbiome may lead to disease.•Knowledge of the oral microbiome can be applied in personalized dentistry.•Personalized dentistry can reflect clinical application and individual populations.•Oral microbiological analysis can be performed at point-of-care hubs. In the e...

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Bibliographic Details
Published in:Archives of oral biology Vol. 104; pp. 7 - 12
Main Authors: Belibasakis, Georgios N., Bostanci, Nagihan, Marsh, Philip D., Zaura, Egija
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.08.2019
Subjects:
Aged
Chair-side diagnostics
Dental Caries - therapy
Dentistry
Dysbiosis
Humans
Microbiota
Mouth - microbiology
Oral disease
Oral ecology
Oral microbiome
Personalized dentistry
Point-of-care
Precision Medicine
Oral ecology
Oral disease
Chair-side diagnostics
Point-of-care
Oral microbiome
Personalized dentistry
ISSN:0003-9969, 1879-1506, 1879-1506
Online Access:Get full text
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Summary:•Dysbiotic changes of the oral microbiome may lead to disease.•Knowledge of the oral microbiome can be applied in personalized dentistry.•Personalized dentistry can reflect clinical application and individual populations.•Oral microbiological analysis can be performed at point-of-care hubs. In the era of personalized medicine, it is imperative that oral health is integrated into this concept. The oral cavity fosters a highly individualized microbiome that has evolved to promote oral health, and which exists in a dynamic balance with the host. Microecological changes to the biology of the mouth [e.g. in the host diet and lifestyle, or status of the immune system] may drive deleterious shifts in the composition or metabolic activity of the oral microbiome [‘dysbiosis’]. This review aims to explore how knowledge of the oral microbiome may be utilized for personalized dentistry at the point-of-care. This is a comprehensive narrative review of the literature, summarizing the perspectives of the authors. The huge increase in recent knowledge on the ecology and microbiology of the oral cavity generated by ‘OMIC’ technologies may indeed be clinically translated to support patient care, in terms of prevention, monitoring, risk classification or early diagnosis. The identified clinical applications may not only include dental caries and periodontal disease, but also dental implants and orthodontics. Population-based applications may include systemic health, pregnancy and elderly populations. Applications of selected oral microbiome and host-related biochemical parameters [e.g. the saliva proteome] for personalized dentistry can be customized for different clinical applications or individual populations, at point-of-care hubs.
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ISSN:0003-9969
1879-1506
1879-1506
DOI:10.1016/j.archoralbio.2019.05.023