Intergenerational and transgenerational epigenetic inheritance in animals

Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and e...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature cell biology Ročník 21; číslo 2; s. 143 - 151
Hlavní autoři: Perez, Marcos Francisco, Lehner, Ben
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.02.2019
Nature Publishing Group
Témata:
631/136/2442
631/337/384
Animals
Base sequence
Biomedical and Life Sciences
Cancer Research
Cell Biology
Deoxyribonucleic acid
Developmental Biology
Disease transmission
DNA
DNA Methylation
DNA replication
DNA sequencing
Environment
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Gametes
Genetic research
Genomics - methods
Germ Cells - cytology
Germ Cells - metabolism
Heredity
Inheritance Patterns - genetics
Life Sciences
Metabolites
Models, Genetic
Molecular genetics
Molecular modelling
Physiology
Progeny
Proteins
Review Article
Ribonucleic acid
RNA
Selection, Genetic
Sperm
Stem Cells
ISSN:1465-7392, 1476-4679, 1476-4679
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which ‘epigenetic’ information is transmitted between generations over different timescales, and the importance of this information for development and physiology. Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Literature Review-3
ObjectType-Review-3
content type line 23
ISSN:1465-7392
1476-4679
1476-4679
DOI:10.1038/s41556-018-0242-9