Correlation structure of grid cells is preserved during sleep

The network of grid cells in the medial entorhinal cortex (MEC) forms a fixed reference frame for mapping physical space. The mechanistic origin of the grid representation is unknown, but continuous attractor network models explain multiple fundamental features of grid cell activity. An untested pre...

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Published in:Nature neuroscience Vol. 22; no. 4; pp. 598 - 608
Main Authors: Gardner, Richard J, Lu, Li, Wernle, Tanja, Moser, May-Britt, Moser, Edvard I
Format: Journal Article
Language:English
Published: United States Nature Publishing Group 01.04.2019
Subjects:
Action Potentials
Animals
Arousal
Brain
Correlation
Cortex (entorhinal)
Disintegration
Entorhinal Cortex - physiology
Firing rate
Grid Cells - physiology
Head direction cells
Hippocampus - physiology
Male
Mapping
Mathematical models
Modules
Offsets
Predictions
Rats, Long-Evans
Recording
Sleep
Spatial Processing - physiology
ISSN:1097-6256, 1546-1726, 1546-1726
Online Access:Get full text
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Summary:The network of grid cells in the medial entorhinal cortex (MEC) forms a fixed reference frame for mapping physical space. The mechanistic origin of the grid representation is unknown, but continuous attractor network models explain multiple fundamental features of grid cell activity. An untested prediction of these models is that the grid cell network should exhibit an activity correlation structure that transcends behavioral states. By recording from MEC cell ensembles during navigation and sleep, we found that spatial phase offsets of grid cells predict arousal-state-independent spike rate correlations. Similarly, state-invariant correlations between conjunctive grid-head direction and pure head direction cells were predicted by their head direction tuning offsets during awake behavior. Grid cells were only weakly correlated across grid modules, and module scale relationships disintegrated during slow-wave sleep, suggesting that grid modules function as independent attractor networks. Collectively, our observations imply that network states in MEC are expressed universally across brain and behavior states.
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ISSN:1097-6256
1546-1726
1546-1726
DOI:10.1038/s41593-019-0360-0