Germline Mutations in HOXB13 and Prostate-Cancer Risk

Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of a homeobox gene, HOXB13, in four families with a history of prostate cancer. Prostate cancer is the most common noncutaneous cancer diagnose...

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Published in:The New England journal of medicine Vol. 366; no. 2; pp. 141 - 149
Main Authors: Ewing, Charles M, Ray, Anna M, Lange, Ethan M, Zuhlke, Kimberly A, Robbins, Christiane M, Tembe, Waibhav D, Wiley, Kathleen E, Isaacs, Sarah D, Isaacs, William B, Johng, Dorhyun, Wang, Yunfei, Bizon, Chris, Yan, Guifang, Gielzak, Marta, Partin, Alan W, Shanmugam, Vijayalakshmi, Izatt, Tyler, Sinari, Shripad, Craig, David W, Zheng, S. Lilly, Walsh, Patrick C, Montie, James E, Xu, Jianfeng, Carpten, John D, Cooney, Kathleen A
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 12.01.2012
Subjects:
Age
Biological and medical sciences
Chromosome 17
Chromosomes, Human, Pair 17
Deoxyribonucleic acid
DNA
DNA sequencing
Genealogy
General aspects
Genetic Linkage
Genetics
Germ-Line Mutation
Gynecology. Andrology. Obstetrics
High-Throughput Nucleotide Sequencing
Homeobox
Homeodomain Proteins - genetics
Humans
Male
Male genital diseases
Medical research
Medical sciences
Men
Middle Aged
Mutation
Nephrology. Urinary tract diseases
Pedigree
Prostate - pathology
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Review boards
Risk assessment
Sequence Analysis, DNA
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
United States > US
Michigan
Medicine
Urinary system disease
Prostate disease
Germ line
Risk factor
Genetics
Risk
Malignant tumor
Mutation
Male genital diseases
Prostate cancer
Cancer
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of a homeobox gene, HOXB13, in four families with a history of prostate cancer. Prostate cancer is the most common noncutaneous cancer diagnosed in men in the United States, with more than 240,000 new cases expected in 2011. 1 Despite the demonstration of a strong familial component, identification of the genetic basis for hereditary prostate cancer has been challenging. Linkage studies of families with hereditary prostate cancer have provided inconsistent results. 2 In contrast, genomewide association studies have led to the identification of more than 30 single-nucleotide polymorphisms (SNPs) that are consistently associated with prostate cancer. 3 However, the magnitude of risk elevation attributed to each individual SNP is low, with an increased elevation in risk by . . .
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Mr. Ewing, Ms. Ray, and Dr. Lange and Drs. Isaacs and Cooney contributed equally to this article.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1110000