Cigarette smoke impairs NK cell-dependent tumor immune surveillance

In this study, we investigated the impact of cigarette smoke on tumor immune surveillance and its consequences to lung tumor burden in a murine lung metastasis model. Cigarette smoke exposure significantly increased the numbers of lung metastases following B16-MO5 melanoma challenge. This effect was...

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Bibliographic Details
Published in:	Journal of Immunology Vol. 178; no. 2; pp. 936 - 943
Main Authors:	Lu, Ling-Min, Zavitz, Caleb C J, Chen, Biao, Kianpour, Sussan, Wan, Yonghong, Stämpfli, Martin R
Format:	Journal Article
Language:	English
Published:	United States 15.01.2007
Subjects:	Animals Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism Cell Line, Tumor Dendritic Cells - immunology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Immunologic Surveillance - drug effects Immunologic Surveillance - immunology Interleukin-12 - deficiency Interleukin-12 - genetics Interleukin-12 - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lectins, C-Type Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Lymphocyte Activation - immunology Mice Mice, Knockout Nicotiana - adverse effects Smoke - adverse effects T-Lymphocytes, Cytotoxic - immunology
ISSN:	0022-1767, 1365-2567
Online Access:	Get full text
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