Early remodeling and loss of light-induced dilation of retinal small arteries in CADASIL

A major hurdle to therapeutic development in cerebral small vessel diseases is the lack of in-vivo method that can be used repeatedly for evaluating directly cerebral microvessels. We hypothesised that Adaptive Optics (AO), which allows resolution images up to 1-2 μm/pixel at retinal level, could pr...

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Vydané v:Journal of cerebral blood flow and metabolism Ročník 44; číslo 7; s. 1089
Hlavní autori: Paques, Michel, Krivosic, Valérie, Castro-Farias, Daniela, Dulière, Cédric, Hervé, Dominique, Chaumette, Céline, Rossant, Florence, Taleb, Abbas, Lebenberg, Jessica, Jouvent, Eric, Tadayoni, Ramin, Chabriat, Hugues
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.07.2024
Predmet:
Adult
Aged
CADASIL - diagnostic imaging
CADASIL - pathology
CADASIL - physiopathology
Female
Humans
Light
Male
Middle Aged
Retinal Artery - diagnostic imaging
Retinal Artery - pathology
Retinal Artery - physiopathology
Vascular Remodeling - physiology
Vasodilation - physiology
adaptive optics
CADASIL
functional
remodeling
retinal vessels
ISSN:1559-7016, 1559-7016
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Popis
Shrnutí:A major hurdle to therapeutic development in cerebral small vessel diseases is the lack of in-vivo method that can be used repeatedly for evaluating directly cerebral microvessels. We hypothesised that Adaptive Optics (AO), which allows resolution images up to 1-2 μm/pixel at retinal level, could provide a biomarker for monitoring vascular changes in CADASIL, a genetic form of such condition. In 98 patients and 35 healthy individuals, the wall to lumen ratio (WLR), outer and inner diameter, wall thickness and wall cross-sectional area were measured in a parapapillary and/or paramacular retinal artery. The ratio of vessel diameters before and after light flicker stimulations was also calculated to measure vasoreactivity (VR). Multivariate mixed-model analysis showed that WLR was increased and associated with a larger wall thickness and smaller internal diameter of retinal arteries in patients. The difference was maximal at the youngest age and gradually reduced with aging. Average VR in patients was less than half of that of controls since the youngest age. Any robust association was found with clinical or imaging manifestations of the disease. Thus, AO enables the detection of early functional or structural vascular alterations in CADASIL but with no obvious link to the clinical or imaging severity.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1559-7016
1559-7016
DOI:10.1177/0271678X241226484