Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-d...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 22; no. 2; pp. 243 - 255
Main Authors:	Schafer, Simon T, Paquola, Apua C M, Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J M, Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N, Marchetto, Maria C, Glass, Christopher K, Mertens, Jerome, Gage, Fred H
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.02.2019
Subjects:	Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - pathology Autism Spectrum Disorder - physiopathology Chromatin Cortex Developmental stages Direct conversion Gene Regulatory Networks Humans Induced Pluripotent Stem Cells - pathology Inhibitory postsynaptic potentials Inhibitory Postsynaptic Potentials - physiology Macrocephaly Nerve Net - physiopathology Neural stem cells Neural Stem Cells - pathology Neurons Neurons - pathology Neurons - physiology Phenotypes Pluripotency Priming Stem cells
ISSN:	1097-6256, 1546-1726, 1546-1726
Online Access:	Get full text
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