ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds

Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or bacterial infection could further impede wound healing. Here, a type of ROS-scavenging hydrogel is developed by using p...

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Published in:Biomaterials Vol. 258; p. 120286
Main Authors: Zhao, He, Huang, Jie, Li, Yan, Lv, Xinjing, Zhou, Huiting, Wang, Hairong, Xu, Yunyun, Wang, Chao, Wang, Jian, Liu, Zhuang
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.11.2020
Subjects:
Bacteria
Bacterial infection
bacterial infections
biocompatible materials
crosslinking
Diabetes Mellitus
granulocyte-macrophage colony-stimulating factor
Humans
Hydrogels
M2 phenotype macrophages
macrophages
phenotype
polyvinyl alcohol
Reactive Oxygen Species
ROS-scavenging hydrogel
therapeutics
Wound closure
Wound Healing
Bacterial infection
ROS-scavenging hydrogel
M2 phenotype macrophages
Wound closure
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or bacterial infection could further impede wound healing. Here, a type of ROS-scavenging hydrogel is developed by using polyvinyl alcohol (PVA) cross-linked by a ROS-responsive linker. The obtained hydrogel could act as an effective ROS-scavenging agent to promote the wound closure by decreasing the ROS level and up-regulating M2 phenotype macrophages around the wound. Importantly, such hydrogel formed in the wound could allow release of therapeutics, including mupirocin to kill bacteria, and granulocyte-macrophage colony-stimulating factor (GM-CSF) to accelerate the wound closure, in responsive to endogenous ROS existing in the wound microenvironment. Remarkably, our drug-loaded ROS-scavenging hydrogel could be employed to effectively treat various types of wounds including difficult-to-heal diabetic wounds with bacterial infection. Therefore, this work presents an effective strategy based on ROS-scavenging hydrogel for wound healing under various kinds of complications. [Display omitted]
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2020.120286