Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells

Tight junctions have recently emerged as essential signaling regulators of proliferation and differentiation in epithelial tissues. Here, we aimed to identify the factors regulating claudin-7 expression in the colon, and analyzed the consequences of claudin-7 overexpression in colorectal carcinoma (...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 68; no. 11; p. 4258
Main Authors:	Darido, Charbel, Buchert, Michael, Pannequin, Julie, Bastide, Pauline, Zalzali, Hassan, Mantamadiotis, Theo, Bourgaux, Jean-François, Garambois, Véronique, Jay, Philippe, Blache, Philippe, Joubert, Dominique, Hollande, Frédéric
Format:	Journal Article
Language:	English
Published:	United States 01.06.2008
Subjects:	Blotting, Western Cell Line, Tumor Cell Polarity - physiology Claudins Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology High Mobility Group Proteins - physiology Humans Membrane Proteins - genetics Microscopy, Confocal Microscopy, Fluorescence Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering SOX9 Transcription Factor TCF Transcription Factors - physiology Transcription Factor 7-Like 2 Protein Transcription Factors - physiology
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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