Modulating effect of cytokines on mechanisms of synaptic plasticity in the brain

After accumulation of data showing that resident brain cells (neurons, astrocytes, and microglia) produce mediators of the immune system, such as cytokines and their receptors under normal physiological conditions, a critical need emerged for investigating the role of these mediators in cognitive pr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Biochemistry (Moscow) Ročník 82; číslo 3; s. 264 - 274
Hlavní autoři: Levin, S. G., Godukhin, O. V.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Moscow Pleiades Publishing 01.03.2017
Springer
Springer Nature B.V
Témata:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Brain
Brain - metabolism
Brain research
Cognitive ability
Cytokines
Cytokines - metabolism
Growth factors
Humans
Immune system
Life Sciences
Microbiology
Nerve Tissue Proteins - metabolism
Neuronal Plasticity - physiology
Neuroplasticity
Observations
Physiological aspects
Plasticity
Review
Tumor necrosis factor-TNF
tumor necrosis factor-alpha
interleukin-1 beta
cytokines
synaptic plasticity
transforming growth factor
interleukin-10
interleukin-6
ISSN:0006-2979, 1608-3040, 1608-3040
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:After accumulation of data showing that resident brain cells (neurons, astrocytes, and microglia) produce mediators of the immune system, such as cytokines and their receptors under normal physiological conditions, a critical need emerged for investigating the role of these mediators in cognitive processes. The major problem for understanding the functional role of cytokines in the mechanisms of synaptic plasticity, de novo neurogenesis, and learning and memory is the small number of investigated cytokines. Existing concepts are based on data from just three proinflammatory cytokines: interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. The amount of information in the literature on the functional role of antiinflammatory cytokines in the mechanisms of synaptic plasticity and cognitive functions of mature mammalian brain is dismally low. However, they are of principle importance for understanding the mechanisms of local information processing in the brain, since they modulate the activity of individual cells and local neural networks, being able to reconstruct the processes of synaptic plasticity and intercellular communication, in general, depending on the local ratio of the levels of different cytokines in certain areas of the brain. Understanding the functional role of cytokines in cellular mechanisms of information processing and storage in the brain would allow developing preventive and therapeutic means for the treatment of neuropathologies related to impairment of these mechanisms.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0006-2979
1608-3040
1608-3040
DOI:10.1134/S000629791703004X