Efficient in vivo direct conversion of fibroblasts into cardiomyocytes using a nanoparticle-based gene carrier

The reprogramming of induced cardiomyocytes (iCMs) has shown potential in regenerative medicine. However, in vivo reprogramming of iCMs is significantly inefficient, and novel gene delivery systems are required to more efficiently and safely induce in vivo reprogramming of iCMs for therapeutic appli...

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Veröffentlicht in:	Biomaterials Jg. 192; S. 500 - 509
Hauptverfasser:	Chang, Yujung, Lee, Euiyeon, Kim, Junyeop, Kwon, Yoo-Wook, Kwon, Youngeun, Kim, Jongpil
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.02.2019
Schlagworte:	Animals cardiac output Cardiac reprogramming Cardiomyocytes Cell Line Cellular Reprogramming Cellular Reprogramming Techniques - methods cytotoxicity fibroblasts Fibroblasts - cytology GATA transcription factors gene transfer Gene Transfer Techniques genes Gold - chemistry Gold nanoparticles Heart regeneration humans In vivo reprogramming Metal Nanoparticles - chemistry Mice Mice, Inbred C57BL myocardial infarction Myocytes, Cardiac - cytology nanocarriers nanogold patients somatic cells Cardiac reprogramming In vivo reprogramming Heart regeneration Cardiomyocytes Gold nanoparticles
ISSN:	0142-9612, 1878-5905, 1878-5905
Online-Zugang:	Volltext
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