Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins

Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spl...

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Bibliographic Details
Published in:	Journal of virology Vol. 71; no. 10; p. 7214
Main Authors:	Niewiesk, S, Eisenhuth, I, Fooks, A, Clegg, J C, Schnorr, J J, Schneider-Schaulies, S, ter Meulen, V
Format:	Journal Article
Language:	English
Published:	United States 01.10.1997
Subjects:	Animals Cell Line Cells, Cultured Female Humans Immune Tolerance Kinetics Lymphocyte Activation Lymphocytes - immunology Lymphocytes - virology Male Measles - immunology Measles virus - immunology Measles virus - physiology Polymerase Chain Reaction Recombinant Proteins - biosynthesis RNA, Messenger - biosynthesis Sigmodontinae Spleen - immunology Spleen - virology Transcription, Genetic Transfection Viral Envelope Proteins - biosynthesis Virus Replication
ISSN:	0022-538X
Online Access:	Get more information
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