Mechanical confinement triggers spreading and migration of immobile cells by deforming nucleus

Cells in vivo are often subject to the challenge of spatial confinement from neighboring cells and extracellular matrix (ECM) that are usually adhesive and deformable. Here, we showed that confinement makes initially quiescent round cells on soft adhesive substrates spread and migrate, exhibiting a...

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Bibliographic Details
Published in:	Biomaterials Vol. 320; p. 123209
Main Authors:	Rao, Ran, Yang, Haoxiang, Qiu, Kailong, Xu, Min, Liu, Hao, Shen, Jinghao, Wang, Weihao, Nie, Runjie, Chen, Huan, Jiang, Hongyuan
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.09.2025
Subjects:	Animals biocompatible materials Cell Adhesion cell movement Cell Movement - physiology Cell Nucleus - metabolism Cell spreading embryogenesis extracellular matrix Extracellular Matrix - metabolism Focal Adhesions - metabolism Humans Inside-out mechanism Mechanical confinement Mechanosensor Mechanotransduction, Cellular metastasis Mice Migration Nucleus phenotype YAP-Signaling Proteins Nucleus Inside-out mechanism Mechanical confinement Migration Mechanosensor Cell spreading
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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