Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis. Pyroptosis tightly controls the inflammatory responses and coordinates antimicrobial host defenses by releasing pro-inf...

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Veröffentlicht in:International journal of biological sciences Jg. 15; H. 7; S. 1345 - 1357
Hauptverfasser: Zeng, Cheng, Wang, Renqing, Tan, Hongmei
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Australia Ivyspring International Publisher Pty Ltd 01.01.2019
Ivyspring International Publisher
Schlagworte:
Activation
Animals
Autophagy
Cardiovascular diseases
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - therapy
Carrier Proteins - metabolism
Caspase
Caspase 1 - metabolism
Caspase-1
Cell death
Cytokines
Diabetes mellitus
Diabetic Cardiomyopathies - metabolism
Health risks
Heart Failure - metabolism
Humans
Hyperhomocysteinemia
Hyperlipidemia
Hypertension
Inflammasomes
Inflammasomes - metabolism
Inflammation
Interleukin 18
Interleukins - metabolism
Lysis
Macrophages - metabolism
Myocarditis - metabolism
Myocarditis - virology
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Pathogenesis
Pyroptosis
Review
Risk analysis
Risk Factors
pyroptosis
NLRP3
cardiovascular diseases
inflammation
caspase-1
inflammasome
ISSN:1449-2288, 1449-2288
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Zusammenfassung:Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis. Pyroptosis tightly controls the inflammatory responses and coordinates antimicrobial host defenses by releasing pro-inflammatory cellular contents, such as interleukin (IL)-1β and IL-18, and consequently expands or sustains inflammation. It is recognized as an important innate immune effector mechanism against intracellular pathogens. The induction of pyroptosis is closely associated with the activation of the NOD-like receptor 3 (NLRP3) inflammasome which has been linked to key cardiovascular risk factors including hyperlipidemia, diabetes, hypertension, obesity, and hyperhomocysteinemia. Emerging evidence has indicated pyroptosis as an important trigger and endogenous regulator of cardiovascular inflammation. Thus, pyroptosis may play an important role in the pathogenesis of cardiovascular diseases. Design of therapeutic strategies targeting the activation of NLRP3 inflammasome and pyroptosis holds promise for the treatment of cardiovascular diseases.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.33568