Neuronal conversion of single-chain tissue-type plasminogen activator into its two-chain form: implications in neurodevelopment, learning, and memory

Tissue-type plasminogen activator (tPA) is a serine protease expressed in the central nervous system (CNS) that exhibits various effects, from neurodevelopment to learning and memory processes. tPA is secreted in its single-chain form (sc-tPA) and can be cleaved into a two-chain form (tc-tPA), with...

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Bibliographic Details
Published in:	Cell death & disease Vol. 16; no. 1; pp. 811 - 11
Main Authors:	Triniac, Hortense, Lebatard, Simon, Roussel, Valerie, Lechevallier, Charlotte, Lebouvier, Laurent, Vivien, Denis, Roussel, Benoit D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.11.2025 Springer Nature B.V Nature Publishing Group
Subjects:	13/106 14/34 14/63 631/378/87 631/45/468 64/60 82/29 Amino acids Animals Antibodies Biochemistry Biochemistry, Molecular Biology Biomedical and Life Sciences Cell Biology Cell Culture Cell surface Cellular Biology Central nervous system Enzymes Experiments Fibrinolysin - metabolism Fibroblasts Growth factors Humans Immunology Isoforms Learning Learning - physiology Life Sciences Memory - physiology Mice Molecular biology Neurodevelopment Neurons Neurons - metabolism Neurons and Cognition Plasmin Plasminogen - metabolism Protein Isoforms - metabolism Proteins Rats Serine proteinase t-Plasminogen activator Tissue Plasminogen Activator - chemistry Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism United States > US
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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