Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

Purpose Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, whic...

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Bibliographic Details
Published in:	Surgery today (Tokyo, Japan) Vol. 55; no. 9; pp. 1269 - 1273
Main Authors:	Omura, Akiisa, Kimura, Toru, Maniwa, Tomohiro, Watabe, Tadashi, Honma, Keiichiro, Shintani, Yasushi, Okami, Jiro
Format:	Journal Article
Language:	English
Published:	Singapore Springer Nature Singapore 01.09.2025 Springer Nature B.V
Subjects:	Adult Aged Antigens Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Endopeptidases Female Fibroblasts Gelatinases - analysis Gelatinases - metabolism Humans Immunohistochemistry - methods Internet resources Lung Neoplasms - diagnosis Lung Neoplasms - secondary Male Medicine Medicine & Public Health Membrane Proteins - analysis Membrane Proteins - metabolism Metastasis Middle Aged Open source software Original Original Article Patients Proteins Retrospective Studies Review boards Serine Endopeptidases - analysis Serine Endopeptidases - metabolism Solitary Fibrous Tumors - diagnosis Solitary Fibrous Tumors - metabolism Solitary Fibrous Tumors - pathology Solitary Fibrous Tumors - surgery Surgery Surgical Oncology Thoracic Neoplasms - diagnosis Thoracic Neoplasms - pathology Tomography Tumors Pleural tumor Malignant potential Solitary fibrous tumor Fibroblast activation protein Diagnostic target
ISSN:	0941-1291, 1436-2813, 1436-2813
Online Access:	Get full text
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