Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

Purpose Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, whic...

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Vydáno v:Surgery today (Tokyo, Japan) Ročník 55; číslo 9; s. 1269 - 1273
Hlavní autoři: Omura, Akiisa, Kimura, Toru, Maniwa, Tomohiro, Watabe, Tadashi, Honma, Keiichiro, Shintani, Yasushi, Okami, Jiro
Médium: Journal Article
Jazyk:angličtina
Vydáno: Singapore Springer Nature Singapore 01.09.2025
Springer Nature B.V
Témata:
Adult
Aged
Antigens
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Endopeptidases
Female
Fibroblasts
Gelatinases - analysis
Gelatinases - metabolism
Humans
Immunohistochemistry - methods
Internet resources
Lung Neoplasms - diagnosis
Lung Neoplasms - secondary
Male
Medicine
Medicine & Public Health
Membrane Proteins - analysis
Membrane Proteins - metabolism
Metastasis
Middle Aged
Open source software
Original
Original Article
Patients
Proteins
Retrospective Studies
Review boards
Serine Endopeptidases - analysis
Serine Endopeptidases - metabolism
Solitary Fibrous Tumors - diagnosis
Solitary Fibrous Tumors - metabolism
Solitary Fibrous Tumors - pathology
Solitary Fibrous Tumors - surgery
Surgery
Surgical Oncology
Thoracic Neoplasms - diagnosis
Thoracic Neoplasms - pathology
Tomography
Tumors
Pleural tumor
Malignant potential
Solitary fibrous tumor
Fibroblast activation protein
Diagnostic target
ISSN:0941-1291, 1436-2813, 1436-2813
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Shrnutí:Purpose Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs. Methods The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath. Results Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP. Conclusion Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0941-1291
1436-2813
1436-2813
DOI:10.1007/s00595-025-03024-y