Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice

NSG-SGM3 and NOG-EXL mice combine severe immunodeficiency with transgenic expression of human myeloid stimulatory cytokines, resulting in marked expansion of myeloid populations upon humanization with CD34+ hematopoietic stem cells (HSCs). Humanized NSG-SGM3 mice typically develop a lethal macrophag...

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Bibliographic Details
Published in:	Veterinary pathology Vol. 61; no. 4; p. 664
Main Authors:	Willis, Elinor, Verrelle, Jillian, Banerjee, Esha, Assenmacher, Charles-Antoine, Tarrant, James C, Skuli, Nicholas, Jacobson, Moriah L, O'Rouke, Donald M, Binder, Zev A, Radaelli, Enrico
Format:	Journal Article
Language:	English
Published:	United States 01.07.2024
Subjects:	Animals Antigens, CD34 - metabolism Disease Models, Animal Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - pathology Humans Mice Mice, Transgenic Myeloid Cells - pathology Phenotype NOG-EXL mouse humanization macrophage activation syndrome hemophagocytic lymphohistiocytosis mast cell hyperplasia NSG-SGM3 human hematopoietic stem cells
ISSN:	1544-2217, 1544-2217
Online Access:	Get more information
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