Novel Role of the SIRT1 in Endocrine and Metabolic Diseases

Silent information regulator 1 (SIRT1), a highly conserved NAD -dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism. The accumulated evidence suggests that SIRT1 is involved in the development...

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Veröffentlicht in:International journal of biological sciences Jg. 19; H. 2; S. 484 - 501
Hauptverfasser: Lu, Chenxi, Zhao, Huadong, Liu, Yanqing, Yang, Zhi, Yao, Hairong, Liu, Tong, Gou, Tiantian, Wang, Li, Zhang, Juan, Tian, Ye, Yang, Yang, Zhang, Huan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Australia Ivyspring International Publisher Pty Ltd 2023
Ivyspring International Publisher
Schlagworte:
Adipocytes
Aging
Apoptosis
Autophagy
Biomarkers
Biomarkers - metabolism
Deacetylation
Diabetes
Diabetes mellitus
Endocrine system
Endocrine System Diseases - diagnosis
Endocrine System Diseases - drug therapy
Endocrine System Diseases - metabolism
Energy metabolism
Female reproductive system
Gene expression
Glucose
Histones
Humans
Hyperlipidemia
Hypertension
Hyperuricemia
Insulin
Kinases
Lipids
Localization
Lysine
Mammals
Melatonin
Metabolic Diseases - diagnosis
Metabolic Diseases - drug therapy
Metabolic Diseases - metabolism
Metabolic disorders
Molecular Targeted Therapy
Osteoporosis
Oxidative stress
Pancreas
Physiology
Polycystic ovary syndrome
Proteins
Review
Senescence
SIRT1 protein
Sirtuin 1 - metabolism
Therapeutic targets
Transcription factors
Transcription Factors - metabolism
inhibitors
agonists
SIRT1
endocrine metabolic
ISSN:1449-2288, 1449-2288
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Zusammenfassung:Silent information regulator 1 (SIRT1), a highly conserved NAD -dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism. The accumulated evidence suggests that SIRT1 is involved in the development of endocrine and metabolic diseases. In a variety of organisms, SIRT1 regulates gene expression through the deacetylation of histone, transcription factors, and lysine residues of other modified proteins including several metabolic and endocrine signal transcription factors, thereby enhancing the therapeutic effects of endocrine and metabolic diseases. These evidences indicate that targeting SIRT1 has promising applications in the treatment of endocrine and metabolic diseases. This review focuses on the role of SIRT1 in endocrine and metabolic diseases. First, we describe the background and structure of SIRT1. Then, we outline the role of SIRT1 in endocrine and metabolic diseases such as hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, and polycystic ovarian syndrome. Subsequently, the SIRT1 agonists and inhibitors in the above diseases are summarized and future research directions are proposed. Overall, the information presents here may highlight the potential of SIRT1 as a future biomarker and therapeutic target for endocrine and metabolic diseases.
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These authors contributed equally to this work.
Competing Interests: The authors have declared that no competing interest exists.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.78654