Pharmacological characterization of the seven human NOX isoforms and their inhibitors

NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the formation of superoxide anion radical (O ) and/or hydrogen peroxide (H O ). As major oxidant generators, NOX are associated with oxidative damage in numerous diseases and represent promising drug targets for several pathologies. Var...

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Veröffentlicht in:	Redox biology Jg. 26; S. 101272
Hauptverfasser:	Augsburger, Fiona, Filippova, Aleksandra, Rasti, Delphine, Seredenina, Tamara, Lam, Magdalena, Maghzal, Ghassan, Mahiout, Zahia, Jansen-Dürr, Pidder, Knaus, Ulla G., Doroshow, James, Stocker, Roland, Krause, Karl-Heinz, Jaquet, Vincent
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier 01.09.2019
Schlagworte:	Catalysis Cell Line Chromatography, Liquid Drug Discovery Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Hydrogen Peroxide - metabolism Isoenzymes Leukocytes - drug effects Leukocytes - metabolism Metabolic Networks and Pathways - drug effects Models, Biological NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Reactive Oxygen Species - metabolism Research Paper Structure-Activity Relationship Tandem Mass Spectrometry Reactive oxygen species Small molecule inhibitors NADPH oxidase NOX
ISSN:	2213-2317, 2213-2317
Online-Zugang:	Volltext
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