Isolation and complete genome characterization of novel reassortant orthoreovirus from common vole (Microtus arvalis)

A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole ( Microtus arvalis ) with Tula hantavirus infection. Seven segments (L1–L3, M2–M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole...

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Bibliographic Details
Published in:Virus genes Vol. 53; no. 2; pp. 307 - 311
Main Authors: Fehér, Enikő, Kemenesi, Gábor, Oldal, Miklós, Kurucz, Kornélia, Kugler, Renáta, Farkas, Szilvia L., Marton, Szilvia, Horváth, Győző, Bányai, Krisztián, Jakab, Ferenc
Format: Journal Article
Language:English
Published: New York Springer US 01.04.2017
Springer Nature B.V
Subjects:
amino acids
Animals
Arvicolinae - genetics
Arvicolinae - virology
Biomedical and Life Sciences
Biomedicine
Clethrionomys glareolus
genome
Germany
Hantavirus - genetics
Hantavirus Infections - genetics
Hantavirus Infections - virology
Humans
lungs
Mammalian orthoreovirus
Medical Microbiology
mice
Microtus arvalis
Molecular Sequence Data
Orthohantavirus
Phylogeny
Plant Sciences
Reassortant Viruses - classification
Reassortant Viruses - genetics
Reassortant Viruses - pathogenicity
Virology
zoonoses
Germany
Orthoreovirus
Hungary
Common vole
Reassortant
ISSN:0920-8569, 1572-994X, 1572-994X
Online Access:Get full text
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Summary:A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole ( Microtus arvalis ) with Tula hantavirus infection. Seven segments (L1–L3, M2–M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole ( Myodes glareolus ) in Germany. The M1 and S3 segment of the Hungarian isolate showed the closest relationship with the sequence of a Slovenian human and a French murine isolate, respectively. The highest nucleotide and amino acid identity values were above 90 and 95% in all of the comparisons to the reference sequences in GenBank, except for the S1 with a maximum of 69.6% nucleotide and 75.4% amino acid identity. As wild rodents are among the main sources of zoonotic infections, the reservoir role of these animals and zoonotic potential of rodent origin MRVs need to be further investigated.
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ISSN:0920-8569
1572-994X
1572-994X
DOI:10.1007/s11262-016-1411-1