Isolation and complete genome characterization of novel reassortant orthoreovirus from common vole (Microtus arvalis)

A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole ( Microtus arvalis ) with Tula hantavirus infection. Seven segments (L1–L3, M2–M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole...

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Vydáno v:	Virus genes Ročník 53; číslo 2; s. 307 - 311
Hlavní autoři:	Fehér, Enikő, Kemenesi, Gábor, Oldal, Miklós, Kurucz, Kornélia, Kugler, Renáta, Farkas, Szilvia L., Marton, Szilvia, Horváth, Győző, Bányai, Krisztián, Jakab, Ferenc
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.04.2017 Springer Nature B.V
Témata:	amino acids Animals Arvicolinae - genetics Arvicolinae - virology Biomedical and Life Sciences Biomedicine Clethrionomys glareolus genome Germany Hantavirus - genetics Hantavirus Infections - genetics Hantavirus Infections - virology Humans lungs Mammalian orthoreovirus Medical Microbiology mice Microtus arvalis Molecular Sequence Data Orthohantavirus Phylogeny Plant Sciences Reassortant Viruses - classification Reassortant Viruses - genetics Reassortant Viruses - pathogenicity Virology zoonoses Germany Orthoreovirus Hungary Common vole Reassortant
ISSN:	0920-8569, 1572-994X, 1572-994X
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Shrnutí:	A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole ( Microtus arvalis ) with Tula hantavirus infection. Seven segments (L1–L3, M2–M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole ( Myodes glareolus ) in Germany. The M1 and S3 segment of the Hungarian isolate showed the closest relationship with the sequence of a Slovenian human and a French murine isolate, respectively. The highest nucleotide and amino acid identity values were above 90 and 95% in all of the comparisons to the reference sequences in GenBank, except for the S1 with a maximum of 69.6% nucleotide and 75.4% amino acid identity. As wild rodents are among the main sources of zoonotic infections, the reservoir role of these animals and zoonotic potential of rodent origin MRVs need to be further investigated.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0920-8569 1572-994X 1572-994X
DOI:	10.1007/s11262-016-1411-1