Alternative complement pathway assessment in patients with atypical HUS

The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy leading to end stage renal disease in approximately 60% of patients. Over the last decade, a clear link has been demonstrated between this disease and defective complement regulation. The hallmark of the aHUS is the a...

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Veröffentlicht in:	Journal of immunological methods Jg. 365; H. 1-2; S. 8 - 26
Hauptverfasser:	Roumenina, Lubka T., Loirat, Chantal, Dragon-Durey, Marie-Agnes, Halbwachs-Mecarelli, Lise, Sautes-Fridman, Catherine, Fremeaux-Bacchi, Veronique
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Amsterdam Elsevier B.V 28.02.2011 Elsevier
Schlagworte:	antibodies Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Atypical Hemolytic Uremic Syndrome Biological and medical sciences C3 convertase Complement Complement blockers Complement C3 - chemistry Complement C3 - genetics Complement C3 - metabolism Complement C3 Convertase, Alternative Pathway - biosynthesis Complement C3 Convertase, Alternative Pathway - chemistry Complement C3 Convertase, Alternative Pathway - genetics Complement Factor B - chemistry Complement Factor B - genetics Complement Factor B - metabolism Complement Factor H - chemistry Complement Factor H - genetics Complement Factor H - metabolism Complement Inactivating Agents - therapeutic use Complement Pathway, Alternative - genetics Complement System Proteins - chemistry Complement System Proteins - genetics Complement System Proteins - metabolism Defective complement regulators Factor H Fundamental and applied biological sciences. Psychology Fundamental immunology genes genetic disorders Genetic Techniques genetic techniques and protocols hemolytic uremic syndrome Hemolytic-Uremic Syndrome - diagnosis Hemolytic-Uremic Syndrome - genetics Hemolytic-Uremic Syndrome - immunology Hemolytic-Uremic Syndrome - therapy Humans Immunologic Tests Kidney Transplantation mechanism of action microangiopathy Models, Molecular Molecular immunology Mutation patients Plasma Exchange protein synthesis screening Techniques therapeutics Complement blockers Defective complement regulators Factor H Complement Atypical Hemolytic Uremic Syndrome C3 convertase Kidney disease Human Thrombocytopenia Urinary system disease Hemolytic uremic syndrome Alternative pathway complement Acute Hemopathy Immunological method Platelet Hemolytic anemia Renal failure
ISSN:	0022-1759, 1872-7905, 1872-7905
Online-Zugang:	Volltext
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