New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels, including a transcriptional level,...

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Bibliographic Details
Published in:Biochemical journal Vol. 366; no. Pt 2; p. 377
Main Authors: Foufelle, Fabienne, Ferré, Pascal
Format: Journal Article
Language:English
Published: England 01.09.2002
Subjects:
Animals
CCAAT-Enhancer-Binding Proteins - metabolism
DNA-Binding Proteins - metabolism
Gene Expression Regulation - drug effects
Glucose - metabolism
Glucose - pharmacology
Glycolysis - drug effects
Glycolysis - genetics
Homeostasis
Humans
Insulin - pharmacology
Liver - metabolism
Sterol Regulatory Element Binding Protein 1
Transcription Factors - metabolism
ISSN:0264-6021
Online Access:Get more information
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Summary:The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels, including a transcriptional level, since many of the metabolism-related genes are expressed according to the quantity and quality of nutrients. Recent advances have been made in the understanding of the regulation of hepatic glycolytic, lipogenic and gluconeogenic gene expression by pancreatic hormones, insulin and glucagon and glucose. Here we review the role of the transcription factors forkhead and sterol regulatory element binding protein-1c in the inductive and repressive effects of insulin on hepatic gene expression, and the pathway that leads from glucose to gene regulation with the recently discovered carbohydrate response element binding protein. We discuss how these transcription factors are integrated in a regulatory network that allows a fine tuning of hepatic glucose storage or production, and their potential importance in metabolic diseases.
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ISSN:0264-6021
DOI:10.1042/bj20020430