TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration‐Resistant Prostate Cancer

The testis‐specific Y‐encoded‐like protein (TSPYL) gene family includes TSPYL1 to TSPYL6. We previously reported that TSPYL5 regulates cytochrome P450 (CYP) 19A1 expression. Here we show that TSPYLs, especially TSPYL 1, 2, and 4, can regulate the expression of many CYP genes, including CYP17A1, a ke...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 104; no. 1; pp. 201 - 210
Main Authors:	Qin, Sisi, Liu, Duan, Kohli, Manish, Wang, Liguo, Vedell, Peter T., Hillman, David W., Niu, Nifang, Yu, Jia, Weinshilboum, Richard M., Wang, Liewei
Format:	Journal Article
Language:	English
Published:	United States 01.07.2018
Subjects:	Abiraterone Acetate - pharmacology Abiraterone Acetate - therapeutic use Cell Cycle Proteins - drug effects Cell Cycle Proteins - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Cytochrome P-450 CYP3A - drug effects Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P-450 Enzyme Inhibitors - therapeutic use Dehydroepiandrosterone - metabolism Gene Expression Regulation - drug effects Gene Knockdown Techniques Hep G2 Cells Humans Male Neoplasm Metastasis Nuclear Proteins - drug effects Nuclear Proteins - genetics Proportional Hazards Models Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - pathology RNA, Messenger - metabolism Steroid 17-alpha-Hydroxylase - antagonists & inhibitors Steroid 17-alpha-Hydroxylase - drug effects Steroid 17-alpha-Hydroxylase - genetics Treatment Outcome
ISSN:	0009-9236, 1532-6535, 1532-6535
Online Access:	Get full text
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