Natural products and their derivatives: Promising modulators of tumor immunotherapy

A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulato...

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Bibliographic Details
Published in:Journal of leukocyte biology Vol. 108; no. 2; pp. 493 - 508
Main Authors: Deng, Li‐Juan, Qi, Ming, Li, Nan, Lei, Yu‐He, Zhang, Dong‐Mei, Chen, Jia‐Xu
Format: Journal Article
Language:English
Published: United States Oxford University Press 01.08.2020
John Wiley and Sons Inc
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
cardiotonic steroids
Cell death
Chemokines
Curcumin
Digoxin
Humans
Immune checkpoint
Immunogenicity
Immunologic Factors - chemistry
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunomodulation
Immunomodulation - drug effects
Immunoregulation
Immunotherapy
Immunotherapy - adverse effects
Immunotherapy - methods
Lentinan
Lymphocytes
Lymphocytes B
Lymphocytes T
Macrophages
MAP kinase
Natural products
Neoplasms - immunology
Neoplasms - therapy
Paclitaxel
polyphenolics
Polyphenols
Polysaccharides
Resveratrol
Review
Steroid hormones
Suppressor cells
Terpenes
terpenoids
Treatment Outcome
Tregs
tumor immunotherapy
Tumors
polyphenolics
polysaccharides
cardiotonic steroids
terpenoids
Tregs
tumor immunotherapy
ISSN:0741-5400, 1938-3673, 1938-3673
Online Access:Get full text
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Summary:A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid‐derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF‐κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research. This review aims to summarize the integrated research progress of natural products (e.g. curcumin) on the tumor immunotherapy and key intracellular pathways.
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ISSN:0741-5400
1938-3673
1938-3673
DOI:10.1002/JLB.3MR0320-444R