SARS‐CoV‐2 antibody kinetics in blood donors with a previously positive SARS‐CoV‐2 antibody test within a seroprevalence survey

The persistence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibodies is a matter of importance regarding the coronavirus disease 19 (COVID‐19) pandemic. To observe antibody dynamics, 105 blood donors, positive for SARS‐CoV‐2 antibodies by a lateral flow test within a seropreval...

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Veröffentlicht in:Journal of medical virology Jg. 94; H. 4; S. 1711 - 1716
Hauptverfasser: Levring, Mette B., Holm, Dorte K., Nilsson, Anna C., Bauer, Joschka M., Jensen, Iben S., Davidsen, Jesper R., Rasmussen, Line D., Sprogøe, Ulrik, Lillevang, Søren T.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.04.2022
John Wiley and Sons Inc
Schlagworte:
Adult
Antibodies
Antibodies, Viral - blood
antibody
Blood
Blood donors
Blood Donors - statistics & numerical data
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - epidemiology
COVID-19 - immunology
Denmark - epidemiology
Enzyme-linked immunosorbent assay
Female
Humans
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin M
Immunoglobulin M - blood
Isotypes
Kinetics
lateral flow test
Male
Pandemics
Reinfection - blood
Reinfection - epidemiology
Reinfection - immunology
SARS-CoV-2 - immunology
SARS‐CoV‐2
Seroepidemiologic Studies
Serology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Short Communication
Signs and symptoms
Statistical analysis
Viral diseases
Virology
Young Adult
Denmark
COVID-19
blood donors
SARS-CoV-2
antibody
lateral flow test
ISSN:0146-6615, 1096-9071, 1096-9071
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Zusammenfassung:The persistence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibodies is a matter of importance regarding the coronavirus disease 19 (COVID‐19) pandemic. To observe antibody dynamics, 105 blood donors, positive for SARS‐CoV‐2 antibodies by a lateral flow test within a seroprevalence study, were included in this study. Thirty‐nine (37%) of 105 the donors were confirmed positive by a total Ig Wantai enzyme‐linked immunosorbent assay (ELISA). Three (8%) in this group of 39 reported severe and 26/39 (67%) mild to moderate COVID‐19 symptoms. By further ELISA‐testing, 33/39 (85%) donors were initially positive for IgG antibodies, 31/39 (79%) for IgA, and 32/39 (82%) for IgM, while 27/39 (69%) were positive for all three isotypes. Persistence of IgG, IgA, and IgM was observed in 73%, 79%, and 32% of donors, respectively, after 6–9 months of observation. For IgM antibodies, the decline in the proportion of positive donors was statistically significant (p = 0.002) during 12 months observation, for IgG only the decline at 3 months was statistically significant (p = 0.042). Four donors exhibited notable increases in antibody levels. In conclusion, persistent SARS‐CoV‐2 IgA antibodies and IgG antibodies at 6–9 months are present in approximately three of four individuals with previous mild to moderate COVID‐19.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.27486