Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need

To date, reperfusion with tissue plasminogen activator (tPA) remains the gold standard treatment for ischemic stroke. However, when tPA is given beyond 4.5 hours of stroke onset, deleterious effects of the drug ensue, especially, hemorrhagic transformation (HT), which causes the most significant mor...

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Bibliographic Details

Published in:	Journal of stroke Vol. 19; no. 1; pp. 50 - 60
Main Authors:	Peña, Ike dela, Borlongan, Cesar, Shen, Guofang, Davis, Willie
Format:	Journal Article
Language:	English
Published:	Korea (South) Korean Stroke Society 01.01.2017 대한뇌졸중학회
Subjects:	blood-brain barrier hemorrhage Review tissue plasminogen activator vasculature 신경과학 Blood-brain barrier Tissue plasminogen activator Hemorrhage Vasculature
ISSN:	2287-6391, 1229-4101, 2287-6405
Online Access:	Get full text
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