The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to endogenous and/or environmental stressors. The coordination of mtDNA replication and transcription regulates the pace of mitochondrial biogenesis...

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Vydané v:	Experimental gerontology Ročník 178; s. 112203
Hlavní autori:	Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Júnior, Hélio José, Leeuwenburgh, Christiaan, Bucci, Cecilia, Marzetti, Emanuele
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Inc 01.07.2023 Elsevier
Predmet:	Aging - genetics Animals DNA Copy Number Variations DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Heteroplasmy Humans Mitochondrial biogenesis Mitochondrial diseases Mitochondrial quality mtDNA deletions mtDNA mutations Mutation Neoplasms - genetics CaMK NRF mtDNA Mitochondrial diseases mtDNA deletions mtDNA4977 Mitochondrial biogenesis TFBM ERR-α AD OriL HSP MERFF OriH LSP mtDNA mutations PGC-1α COX Mitochondrial quality MCI PD Heteroplasmy ETC NUMTs LHON AMPK TFAM Sirt1 D-loop MELAS CJD
ISSN:	0531-5565, 1873-6815, 1873-6815
On-line prístup:	Získať plný text
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