The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to endogenous and/or environmental stressors. The coordination of mtDNA replication and transcription regulates the pace of mitochondrial biogenesis...

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Bibliographic Details
Published in:	Experimental gerontology Vol. 178; p. 112203
Main Authors:	Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Júnior, Hélio José, Leeuwenburgh, Christiaan, Bucci, Cecilia, Marzetti, Emanuele
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01.07.2023 Elsevier
Subjects:	Aging - genetics Animals DNA Copy Number Variations DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Heteroplasmy Humans Mitochondrial biogenesis Mitochondrial diseases Mitochondrial quality mtDNA deletions mtDNA mutations Mutation Neoplasms - genetics CaMK NRF mtDNA Mitochondrial diseases mtDNA deletions mtDNA4977 Mitochondrial biogenesis TFBM ERR-α AD OriL HSP MERFF OriH LSP mtDNA mutations PGC-1α COX Mitochondrial quality MCI PD Heteroplasmy ETC NUMTs LHON AMPK TFAM Sirt1 D-loop MELAS CJD
ISSN:	0531-5565, 1873-6815, 1873-6815
Online Access:	Get full text
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