Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection. The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory inf...

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Veröffentlicht in:Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) Jg. 6; H. 4; S. 231 - 236
Hauptverfasser: Lowery, Megan M., Taimur Malik, Muhammad, Seemiller, Joseph, Tsai, Cynthia S.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Poland Sciendo 01.10.2020
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Schlagworte:
Antibodies
Ataxia
Case Report
Coronaviruses
COVID-19
Cytomegalovirus
Diagnostic tests
Guillain Barre Syndrome
Hospitals
hypoxemic and hypercapnic respiratory failure
Immunoglobulins
Immunology
Influenza
Intubation
Magnetic resonance imaging
Miller Fisher Syndrome
Ostomy
Polymerase chain reaction
Proteins
Respiratory diseases
Respiratory failure
SARS-CoV-2
Severe acute respiratory syndrome
Tracheotomy
Ventilators
Weaning
United States > US
COVID-19
SARS-CoV-2
Miller Fisher Syndrome
hypoxemic and hypercapnic respiratory failure
Guillain Barre Syndrome
ISSN:2393-1817, 2393-1809, 2393-1817
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection. The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory infection symptoms began. A nasopharyngeal swab was positive for COVID-19 polymerase chain reaction. He progressed to acute hypoxemic and hypercapnic respiratory failure requiring intubation and rapidly developed tetraparesis. Magnetic resonance imaging of the spine was consistent with Guillain Barre Syndrome. However, the clinical symptoms, along with positive anti-GQ1B antibodies, were consistent with Miller Fisher Syndrome and Guillain Barre Syndrome overlap. The patient required tracheostomy and had limited improvement in his significant neurological symptoms after several months. The case demonstrates the severe neurological implications, prolonged recovery and implications in the concomitant respiratory failure of COVID-19 patients with neurological symptoms on the spectrum of disorders of Guillain Barre Syndrome.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-4
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ISSN:2393-1817
2393-1809
2393-1817
DOI:10.2478/jccm-2020-0038