Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection. The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory inf...

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Vydáno v:	Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) Ročník 6; číslo 4; s. 231 - 236
Hlavní autoři:	Lowery, Megan M., Taimur Malik, Muhammad, Seemiller, Joseph, Tsai, Cynthia S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Poland Sciendo 01.10.2020 De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Témata:	Antibodies Ataxia Case Report Coronaviruses COVID-19 Cytomegalovirus Diagnostic tests Guillain Barre Syndrome Hospitals hypoxemic and hypercapnic respiratory failure Immunoglobulins Immunology Influenza Intubation Magnetic resonance imaging Miller Fisher Syndrome Ostomy Polymerase chain reaction Proteins Respiratory diseases Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome Tracheotomy Ventilators Weaning United States > US COVID-19 SARS-CoV-2 Miller Fisher Syndrome hypoxemic and hypercapnic respiratory failure Guillain Barre Syndrome
ISSN:	2393-1817, 2393-1809, 2393-1817
On-line přístup:	Získat plný text
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Popis
Shrnutí:	A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection. The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory infection symptoms began. A nasopharyngeal swab was positive for COVID-19 polymerase chain reaction. He progressed to acute hypoxemic and hypercapnic respiratory failure requiring intubation and rapidly developed tetraparesis. Magnetic resonance imaging of the spine was consistent with Guillain Barre Syndrome. However, the clinical symptoms, along with positive anti-GQ1B antibodies, were consistent with Miller Fisher Syndrome and Guillain Barre Syndrome overlap. The patient required tracheostomy and had limited improvement in his significant neurological symptoms after several months. The case demonstrates the severe neurological implications, prolonged recovery and implications in the concomitant respiratory failure of COVID-19 patients with neurological symptoms on the spectrum of disorders of Guillain Barre Syndrome.
Bibliografie:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Report-1 ObjectType-Feature-4 content type line 23 ObjectType-Article-3
ISSN:	2393-1817 2393-1809 2393-1817
DOI:	10.2478/jccm-2020-0038